Pauline Wang

Pauline Wang, PhD.
Senior Research Associate

Education:
Ph.D. State University of New York at Stony Brook
B.Sc. Rensselaer Polytechnic Institute

 

 

 

Contact information:
Office: ESC 4035
Lab: ESC 4038/4039
Lab phone: 416-946-7121
Email: pauline.wang@utoronto.ca

Publications:

  1. Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.
    Layeghifard, M, Li, H, Wang, PW, Donaldson, SL, Coburn, B, Clark, ST, Caballero, JD, Zhang, Y, Tullis, DE, Yau, YCW, Waters, V, Hwang, DM, Guttman, DS.
    NPJ Biofilms Microbiomes.5,2019. PubMed PMID:30675371
  2. Penicillin binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.
    Clark, ST, Sinha, U, Zhang, Y, Wang, PW, Donaldson, SL, Coburn, B, Waters, VJ, Yau, YCW, Tullis, DE, Guttman, DS, Hwang, DM.
    Int. J. Antimicrob. Agents.,2019. PubMed PMID:30664925
  3. Recombination of ecologically and evolutionarily significant loci maintains genetic cohesion in the Pseudomonas syringae species complex.
    Dillon, MM, Thakur, S, Almeida, RND, Wang, PW, Weir, BS, Guttman, DS.
    Genome Biol.20,2019. PubMed PMID:30606234
  4. Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen.
    Lee, AH, Bastedo, DP, Youn, JY, Lo, T, Middleton, MA, Kireeva, I, Lee, JY, Sharifpoor, S, Baryshnikova, A, Zhang, J, Wang, PW, Peisajovich, SG, Constanzo, M, Andrews, BJ, Boone, CM, Desveaux, D, Guttman, DS.
    G3 (Bethesda).9,2019. PubMed PMID:30573466
  5. Design and application of a novel two-amplicon approach for defining eukaryotic microbiota.
    Popovic, A, Bourdon, C, Wang, PW, Guttman, DS, Voskuijl, W, Grigg, ME, Bandsma, RHJ, Parkinson, J.
    Microbiome.6,2018. PubMed PMID:30572961
  6. A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.
    Diaz Caballero, J, Clark, ST, Wang, PW, Donaldson, SL, Coburn, B, Tullis, DE, Yau, YCW, Waters, VJ, Hwang, DM, Guttman, DS.
    PLoS Pathog.14,2018. PubMed PMID:30532201
  7. Chloroplast sequence variation and the efficacy of peptide nucleic acids for blocking host amplification in plant microbiome studies.
    Fitzpatrick, CR, Lu-Irving, P, Copeland, J, Guttman, DS, Wang, PW, Baltrus, DA, Dlugosch, KM, Johnson, MTJ.
    Microbiome.6,2018. PubMed PMID:30121081
  8. Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population.
    Middleton, MA, Layeghifard, M, Klingel, M, Stanojevic, S, Yau, YCW, Zlosnik, JEA, Coriati, A, Ratjen, FA, Tullis, ED, Stephenson, A, Wilcox, P, Freitag, A, Chilvers, M, McKinney, M, Lavoie, A, Wang, PW, Guttman, DS, Waters, VJ.
    Ann Am Thorac Soc.15,2018. PubMed PMID:29911888
  9. Assembly and ecological function of the root microbiome across angiosperm plant species.
    Fitzpatrick, CR, Copeland, J, Wang, PW, Guttman, DS, Kotanen, PM, Johnson, MTJ.
    Proc. Natl. Acad. Sci. U.S.A.115,2018. PubMed PMID:29358405
  10. Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance.
    Beaudoin, T, Yau, YCW, Stapleton, PJ, Gong, Y, Wang, PW, Guttman, DS, Waters, V.
    NPJ Biofilms Microbiomes.3,2017. PubMed PMID:29062489
  11. Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.
    Mott, GA, Thakur, S, Smakowska, E, Wang, PW, Belkhadir, Y, Desveaux, D, Guttman, DS.
    Genome Biol.17,2016. PubMed PMID:27160854
  12. Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
    Kim, SH, Clark, ST, Surendra, A, Copeland, JK, Wang, PW, Ammar, R, Collins, C, Tullis, DE, Nislow, C, Hwang, DM, Guttman, DS, Cowen, LE.
    PLoS Pathog.11,2015. PubMed PMID:26588216
  13. Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
    Diaz Caballero, J, Clark, ST, Coburn, B, Zhang, Y, Wang, PW, Donaldson, SL, Tullis, DE, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
    MBio.6,2015. PubMed PMID:26330513
  14. Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
    Clark, ST, Diaz Caballero, J, Cheang, M, Coburn, B, Wang, PW, Donaldson, SL, Zhang, Y, Liu, M, Keshavjee, S, Yau, YC, Waters, VJ, Elizabeth Tullis, D, Guttman, DS, Hwang, DM.
    Sci Rep.5,2015. PubMed PMID:26047320
  15. Lung microbiota across age and disease stage in cystic fibrosis.
    Coburn, B, Wang, PW, Diaz Caballero, J, Clark, ST, Brahma, V, Donaldson, S, Zhang, Y, Surendra, A, Gong, Y, Elizabeth Tullis, D, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
    Sci Rep.5,2015. PubMed PMID:25974282
  16. Seasonal community succession of the phyllosphere microbiome.
    Copeland, JK, Yuan, L, Layeghifard, M, Wang, PW, Guttman, DS.
    Mol. Plant Microbe Interact.28,2015. PubMed PMID:25679538
  17. The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.
    Lewis, JD, Lee, AH, Hassan, JA, Wan, J, Hurley, B, Jhingree, JR, Wang, PW, Lo, T, Youn, JY, Guttman, DS, Desveaux, D.
    Proc. Natl. Acad. Sci. U.S.A.110,2013. PubMed PMID:24170858
  18. Genomic analysis of the Kiwifruit pathogen Pseudomonas syringae pv. actinidiae provides insight into the origins of an emergent plant disease.
    McCann, HC, Rikkerink, EH, Bertels, F, Fiers, M, Lu, A, Rees-George, J, Andersen, MT, Gleave, AP, Haubold, B, Wohlers, MW, Guttman, DS, Wang, PW, Straub, C, Vanneste, JL, Vanneste, J, Rainey, PB, Templeton, MD.
    PLoS Pathog.9,2013. PubMed PMID:23935484
  19. Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
    Schreiber, KJ, Austin, RS, Gong, Y, Zhang, J, Fung, P, Wang, PW, Guttman, DS, Desveaux, D.
    BMC Plant Biol.12,2012. PubMed PMID:23176361
  20. Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.
    Maughan, H, Wang, PW, Diaz Caballero, J, Fung, P, Gong, Y, Donaldson, SL, Yuan, L, Keshavjee, S, Zhang, Y, Yau, YC, Waters, VJ, Tullis, DE, Hwang, DM, Guttman, DS.
    PLoS ONE.7,2012. PubMed PMID:23056217
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