Publications

2016
 

A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.
Thakur, S, Guttman, DS.
BMC Bioinformatics.17,2016. PubMed PMID:27363390

Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.
Mott, GA, Thakur, S, Smakowska, E, Wang, PW, Belkhadir, Y, Desveaux, D, Guttman, DS.
Genome Biol.17,2016. PubMed PMID:27160854

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo, T, Koulena, N, Seto, D, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.,2016. PubMed PMID:27061875

Phytopathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae Type and Pathotype Strains.
Thakur, S, Weir, BS, Guttman, DS.
Mol. Plant Microbe Interact.29,2016. PubMed PMID:26883489

Search PubMed

2015
 

Elevated Temperature Differentially Influences Effector-Triggered Immunity Outputs in Arabidopsis.
Menna, A, Nguyen, D, Guttman, DS, Desveaux, D.
Front Plant Sci.6,2015. PubMed PMID:26617631

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
Kim, SH, Clark, ST, Surendra, A, Copeland, JK, Wang, PW, Ammar, R, Collins, C, Tullis, DE, Nislow, C, Hwang, DM, Guttman, DS, Cowen, LE.
PLoS Pathog.11,2015. PubMed PMID:26588216

Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
Diaz Caballero, J, Clark, ST, Coburn, B, Zhang, Y, Wang, PW, Donaldson, SL, Tullis, DE, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
MBio.6,2015. PubMed PMID:26330513

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
Clark, ST, Diaz Caballero, J, Cheang, M, Coburn, B, Wang, PW, Donaldson, SL, Zhang, Y, Liu, M, Keshavjee, S, Yau, YC, Waters, VJ, Elizabeth Tullis, D, Guttman, DS, Hwang, DM.
Sci Rep.5,2015. PubMed PMID:26047320

The human microbiome.
Coburn, B, Guttman, DS.
CMAJ.187,2015. PubMed PMID:25991836

Lung microbiota across age and disease stage in cystic fibrosis.
Coburn, B, Wang, PW, Diaz Caballero, J, Clark, ST, Brahma, V, Donaldson, S, Zhang, Y, Surendra, A, Gong, Y, Elizabeth Tullis, D, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
Sci Rep.5,2015. PubMed PMID:25974282

Seasonal community succession of the phyllosphere microbiome.
Copeland, JK, Yuan, L, Layeghifard, M, Wang, PW, Guttman, DS.
Mol. Plant Microbe Interact.28,2015. PubMed PMID:25679538

Search PubMed

2014
 

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
Lewis, JD, Wilton, M, Mott, GA, Lu, W, Hassan, JA, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25546415

Proteomics of effector-triggered immunity (ETI) in plants.
Hurley, B, Subramaniam, R, Guttman, DS, Desveaux, D.
Virulence.5,2014. PubMed PMID:25513776

Peptides and small molecules of the plant-pathogen apoplastic arena.
Mott, GA, Middleton, MA, Desveaux, D, Guttman, DS.
Front Plant Sci.5,2014. PubMed PMID:25506352

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.
Hurley, B, Lee, D, Mott, A, Wilton, M, Liu, J, Liu, YC, Angers, S, Coaker, G, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25503437

Opinion: Conservation and stewardship of the human microbiome.
O’Doherty, KC, Neufeld, JD, Brinkman, FS, Gardner, H, Guttman, DS, Beiko, RG.
Proc. Natl. Acad. Sci. U.S.A.111,2014. PubMed PMID:25294925

Microbial genome-enabled insights into plant-microorganism interactions.
Guttman, DS, McHardy, AC, Schulze-Lefert, P.
Nat. Rev. Genet.15,2014. PubMed PMID:25266034

The rise of the undead: pseudokinases as mediators of effector-triggered immunity.
Lewis, JD, Lo, T, Bastedo, P, Guttman, DS, Desveaux, D.
Plant Signal Behav.9,2014. PubMed PMID:24398910

Next-generation mapping of genetic mutations using bulk population sequencing.
Austin, RS, Chatfield, SP, Desveaux, D, Guttman, DS.
Methods Mol. Biol.1062,2014. PubMed PMID:24057374

Search PubMed

2013
 

The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.
Lewis, JD, Lee, AH, Hassan, JA, Wan, J, Hurley, B, Jhingree, JR, Wang, PW, Lo, T, Youn, JY, Guttman, DS, Desveaux, D.
Proc. Natl. Acad. Sci. U.S.A.110,2013. PubMed PMID:24170858

Phytopathogen type III effectors as probes of biological systems.
Lee, AH, Middleton, MA, Guttman, DS, Desveaux, D.
Microb Biotechnol.6,2013. PubMed PMID:23433088

Search PubMed

2012
 

Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
Schreiber, KJ, Austin, RS, Gong, Y, Zhang, J, Fung, P, Wang, PW, Guttman, DS, Desveaux, D.
BMC Plant Biol.12,2012. PubMed PMID:23176361

Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.
Maughan, H, Wang, PW, Diaz Caballero, J, Fung, P, Gong, Y, Donaldson, SL, Yuan, L, Keshavjee, S, Zhang, Y, Yau, YC, Waters, VJ, Tullis, DE, Hwang, DM, Guttman, DS.
PLoS ONE.7,2012. PubMed PMID:23056217

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Waters, V, Zlosnik, JE, Yau, YC, Speert, DP, Aaron, SD, Guttman, DS.
Eur. J. Clin. Microbiol. Infect. Dis.31,2012. PubMed PMID:22843295

Extensive remodeling of the Pseudomonas syringae pv. avellanae type III secretome associated with two independent host shifts onto hazelnut.
O’Brien, HE, Thakur, S, Gong, Y, Fung, P, Zhang, J, Yuan, L, Wang, PW, Yong, C, Scortichini, M, Guttman, DS.
BMC Microbiol.12,2012. PubMed PMID:22800299

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.
Maughan, H, Cunningham, KS, Wang, PW, Zhang, Y, Cypel, M, Chaparro, C, Tullis, DE, Waddell, TK, Keshavjee, S, Liu, M, Guttman, DS, Hwang, DM.
Pulm Med.2012,2012. PubMed PMID:22448327

Identification of innate immunity elicitors using molecular signatures of natural selection.
McCann, HC, Nahal, H, Thakur, S, Guttman, DS.
Proc. Natl. Acad. Sci. U.S.A.109,2012. PubMed PMID:22323605

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.
Lee, AH, Hurley, B, Felsensteiner, C, Yea, C, Ckurshumova, W, Bartetzko, V, Wang, PW, Quach, V, Lewis, JD, Liu, YC, Börnke, F, Angers, S, Wilde, A, Guttman, DS, Desveaux, D.
PLoS Pathog.8,2012. PubMed PMID:22319451

Quantitative Interactor Screening with next-generation Sequencing (QIS-Seq) identifies Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2.
Lewis, JD, Wan, J, Ford, R, Gong, Y, Fung, P, Nahal, H, Wang, PW, Desveaux, D, Guttman, DS.
BMC Genomics.13,2012. PubMed PMID:22230763

E622, a miniature, virulence-associated mobile element.
Stavrinides, J, Kirzinger, MW, Beasley, FC, Guttman, DS.
J. Bacteriol.194,2012. PubMed PMID:22081398

Search PubMed

2011
 

Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.
O’Brien, HE, Gong, Y, Fung, P, Wang, PW, Guttman, DS.
PLoS ONE.6,2011. PubMed PMID:22073286

The YopJ superfamily in plant-associated bacteria.
Lewis, JD, Lee, A, Ma, W, Zhou, H, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.12,2011. PubMed PMID:21726386

Evolution of plant pathogenesis in Pseudomonas syringae: a genomics perspective.
O’Brien, HE, Thakur, S, Guttman, DS.
Annu Rev Phytopathol.49,2011. PubMed PMID:21568703

Next-generation mapping of Arabidopsis genes.
Austin, RS, Vidaurre, D, Stamatiou, G, Breit, R, Provart, NJ, Bonetta, D, Zhang, J, Fung, P, Gong, Y, Wang, PW, McCourt, P, Guttman, DS.
Plant J.67,2011. PubMed PMID:21518053

Next-generation genomics of Pseudomonas syringae.
O’Brien, HE, Desveaux, D, Guttman, DS.
Curr. Opin. Microbiol.14,2011. PubMed PMID:21233007

Search PubMed

2010
 

Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein.
Lewis, JD, Wu, R, Guttman, DS, Desveaux, D.
PLoS Genet.6,2010. PubMed PMID:20368970

Search PubMed

2009
 

Bacterial evolution: dynamic genomes and the power of transformation.
Guttman, DS.
Curr. Biol.19,2009. PubMed PMID:19788881

The targeting of plant cellular systems by injected type III effector proteins.
Lewis, JD, Guttman, DS, Desveaux, D.
Semin. Cell Dev. Biol.20,2009. PubMed PMID:19540926

Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems.
Zhou, H, Morgan, RL, Guttman, DS, Ma, W.
Mol. Plant Microbe Interact.22,2009. PubMed PMID:19132870

Search PubMed

2008
 

Evolution of prokaryotic and eukaryotic virulence effectors.
Ma, W, Guttman, DS.
Curr. Opin. Plant Biol.11,2008. PubMed PMID:18585954

New and sensitive assay for determining Pseudomonas aeruginosa metallo-beta-lactamase resistance to imipenem.
Tan, J, Pitout, JD, Guttman, DS.
J. Clin. Microbiol.46,2008. PubMed PMID:18337388

The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thaliana.
Lewis, JD, Abada, W, Ma, W, Guttman, DS, Desveaux, D.
J. Bacteriol.190,2008. PubMed PMID:18263728

Evolution of the type III secretion system and its effectors in plant-microbe interactions.
McCann, HC, Guttman, DS.
New Phytol.177,2008. PubMed PMID:18078471

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865

Search PubMed

2007
 

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865

Convergent evolution of phytopathogenic pseudomonads onto hazelnut.
Wang, PW, Morgan, RL, Scortichini, M, Guttman, DS.
Microbiology (Reading, Engl.).153,2007. PubMed PMID:17600051

Search PubMed

2006
 

Type III effector diversification via both pathoadaptation and horizontal transfer in response to a coevolutionary arms race.
Ma, W, Dong, FF, Stavrinides, J, Guttman, DS.
PLoS Genet.2,2006. PubMed PMID:17194219

Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Vencato, M, Tian, F, Alfano, JR, Buell, CR, Cartinhour, S, DeClerck, GA, Guttman, DS, Stavrinides, J, Joardar, V, Lindeberg, M, Bronstein, PA, Mansfield, JW, Myers, CR, Collmer, A, Schneider, DJ.
Mol. Plant Microbe Interact.19,2006. PubMed PMID:17073302

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens.
Stavrinides, J, Ma, W, Guttman, DS.
PLoS Pathog.2,2006. PubMed PMID:17040127

Comparative genomics of host-specific virulence in Pseudomonas syringae.
Sarkar, SF, Gordon, JS, Martin, GB, Guttman, DS.
Genetics.174,2006. PubMed PMID:16951068

Diversifying selection drives the evolution of the type III secretion system pilus of Pseudomonas syringae.
Guttman, DS, Gropp, SJ, Morgan, RL, Wang, PW.
Mol. Biol. Evol.23,2006. PubMed PMID:16950758

Search PubMed

2005
 

Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae.
Hwang, MS, Morgan, RL, Sarkar, SF, Wang, PW, Guttman, DS.
Appl. Environ. Microbiol.71,2005. PubMed PMID:16151103

Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae.
Lindeberg, M, Stavrinides, J, Chang, JH, Alfano, JR, Collmer, A, Dangl, JL, Greenberg, JT, Mansfield, JW, Guttman, DS.
Mol. Plant Microbe Interact.18,2005. PubMed PMID:15828679

Search PubMed

2004
 

Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringae.
Rohmer, L, Guttman, DS, Dangl, JL.
Genetics.167,2004. PubMed PMID:15280247

Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.
Stavrinides, J, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:15262947

Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.
Sarkar, SF, Guttman, DS.
Appl. Environ. Microbiol.70,2004. PubMed PMID:15066790

Plants as models for the study of human pathogenesis.
Guttman, DS.
Biotechnol. Adv.22,2004. PubMed PMID:15063457

The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.
Gropp, SJ, Guttman, DS.
Mol. Plant Pathol.5,2004. PubMed PMID:20565590

Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.
Wang, PW, Chu, L, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:14702309

Mosaic evolution of the severe acute respiratory syndrome coronavirus.
Stavrinides, J, Guttman, DS.
J. Virol.78,2004. PubMed PMID:14671089

Search PubMed

2003
Search PubMed
2002
 

A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.
Guttman, DS, Vinatzer, BA, Sarkar, SF, Ranall, MV, Kettler, G, Greenberg, JT.
Science.295,2002. PubMed PMID:11872842

Search PubMed

2001
 

Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system.
Guttman, DS, Greenberg, JT.
Mol. Plant Microbe Interact.14,2001. PubMed PMID:11204777

Search PubMed

2000
Search PubMed
Earlier Publications
 

An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.
Guttman, DS, Charlesworth, D.
Nature.393,1998. PubMed PMID:9607762

Recombination and clonality in natural populations of Escherichia coli.
Guttman, DS.
Trends Ecol. Evol. (Amst.).12,1997. PubMed PMID:21237956

Seeing selection in S allele sequences.
Charlesworth, D, Guttman, DS.
Curr. Biol.7,1997. PubMed PMID:9072167

Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Guttman, DS, Wang, PW, Wang, IN, Bosler, EM, Luft, BJ, Dykhuizen, DE.
J. Clin. Microbiol.34,1996. PubMed PMID:8904432

Detecting selective sweeps in naturally occurring Escherichia coli.
Guttman, DS, Dykhuizen, DE.
Genetics.138,1994. PubMed PMID:7896119

Clonal divergence in Escherichia coli as a result of recombination, not mutation.
Guttman, DS, Dykhuizen, DE.
Science.266,1994. PubMed PMID:7973728

Search PubMed

2016

Gene Slider: sequence logo interactive data-visualization for education and research.
Waese, J, Pasha, A, Wang, TT, van Weringh, A, Guttman, DS, Provart, NJ.
Bioinformatics.,2016. PubMed PMID:27522081

A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.
Thakur, S, Guttman, DS.
BMC Bioinformatics.17,2016. PubMed PMID:27363390

Prophages mediate defense against phage infection through diverse mechanisms.
Bondy-Denomy, J, Qian, J, Westra, ER, Buckling, A, Guttman, DS, Davidson, AR, Maxwell, KL.
ISME J.,2016. PubMed PMID:27258950

High fecal IgA is associated with reduced Clostridium difficile colonization in infants.
Bridgman, SL, Konya, T, Azad, MB, Guttman, DS, Sears, MR, Becker, AB, Turvey, SE, Mandhane, PJ, Subbarao, P, CHILD Study Investigators, Scott, JA, Field, CJ, Kozyrskyj, AL.
Microbes Infect.18,2016. PubMed PMID:27235197

Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.
Mott, GA, Thakur, S, Smakowska, E, Wang, PW, Belkhadir, Y, Desveaux, D, Guttman, DS.
Genome Biol.17,2016. PubMed PMID:27160854

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo, T, Koulena, N, Seto, D, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.,2016. PubMed PMID:27061875

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.
Ryczko, MC, Pawling, J, Chen, R, Abdel Rahman, AM, Yau, K, Copeland, JK, Zhang, C, Surendra, A, Guttman, DS, Figeys, D, Dennis, JW.
Sci Rep.6,2016. PubMed PMID:26972830

Phytopathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae Type and Pathotype Strains.
Thakur, S, Weir, BS, Guttman, DS.
Mol. Plant Microbe Interact.29,2016. PubMed PMID:26883489

Chronic infection phenotypes of Pseudomonas aeruginosa are associated with failure of eradication in children with cystic fibrosis.
Vidya, P, Smith, L, Beaudoin, T, Yau, YC, Clark, S, Coburn, B, Guttman, DS, Hwang, DM, Waters, V.
Eur. J. Clin. Microbiol. Infect. Dis.35,2016. PubMed PMID:26492874

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
Azad, MB, Konya, T, Persaud, RR, Guttman, DS, Chari, RS, Field, CJ, Sears, MR, Mandhane, PJ, Turvey, SE, Subbarao, P, Becker, AB, Scott, JA, Kozyrskyj, AL, CHILD Study Investigators.
BJOG.123,2016. PubMed PMID:26412384

Search PubMed
2015

Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola.
Sistrom, M, Park, D, O'Brien, HE, Wang, Z, Guttman, DS, Townsend, JP, Turner, PE.
PLoS ONE.10,2015. PubMed PMID:26670219

Elevated Temperature Differentially Influences Effector-Triggered Immunity Outputs in Arabidopsis.
Menna, A, Nguyen, D, Guttman, DS, Desveaux, D.
Front Plant Sci.6,2015. PubMed PMID:26617631

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
Kim, SH, Clark, ST, Surendra, A, Copeland, JK, Wang, PW, Ammar, R, Collins, C, Tullis, DE, Nislow, C, Hwang, DM, Guttman, DS, Cowen, LE.
PLoS Pathog.11,2015. PubMed PMID:26588216

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
Azad, MB, Konya, T, Persaud, RR, Guttman, DS, Chari, RS, Field, CJ, Sears, MR, Mandhane, PJ, Turvey, SE, Subbarao, P, Becker, AB, Scott, JA, Kozyrskyj, AL, CHILD Study Investigators.
BJOG.123,2016. PubMed PMID:26412384

Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
Diaz Caballero, J, Clark, ST, Coburn, B, Zhang, Y, Wang, PW, Donaldson, SL, Tullis, DE, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
MBio.6,2015. PubMed PMID:26330513

Comparative genomic analysis of multiple strains of two unusual plant pathogens: Pseudomonas corrugata and Pseudomonas mediterranea.
Trantas, EA, Licciardello, G, Almeida, NF, Witek, K, Strano, CP, Duxbury, Z, Ververidis, F, Goumas, DE, Jones, JD, Guttman, DS, Catara, V, Sarris, PF.
Front Microbiol.6,2015. PubMed PMID:26300874

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
Clark, ST, Diaz Caballero, J, Cheang, M, Coburn, B, Wang, PW, Donaldson, SL, Zhang, Y, Liu, M, Keshavjee, S, Yau, YC, Waters, VJ, Elizabeth Tullis, D, Guttman, DS, Hwang, DM.
Sci Rep.5,2015. PubMed PMID:26047320

The human microbiome.
Coburn, B, Guttman, DS.
CMAJ.187,2015. PubMed PMID:25991836

Lung microbiota across age and disease stage in cystic fibrosis.
Coburn, B, Wang, PW, Diaz Caballero, J, Clark, ST, Brahma, V, Donaldson, S, Zhang, Y, Surendra, A, Gong, Y, Elizabeth Tullis, D, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
Sci Rep.5,2015. PubMed PMID:25974282

Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.
Luck, H, Tsai, S, Chung, J, Clemente-Casares, X, Ghazarian, M, Revelo, XS, Lei, H, Luk, CT, Shi, SY, Surendra, A, Copeland, JK, Ahn, J, Prescott, D, Rasmussen, BA, Chng, MH, Engleman, EG, Girardin, SE, Lam, TK, Croitoru, K, Dunn, S, Philpott, DJ, Guttman, DS, Woo, M, Winer, S, Winer, DA.
Cell Metab.21,2015. PubMed PMID:25863246

Seasonal community succession of the phyllosphere microbiome.
Copeland, JK, Yuan, L, Layeghifard, M, Wang, PW, Guttman, DS.
Mol. Plant Microbe Interact.28,2015. PubMed PMID:25679538

Infant gut microbiota and food sensitization: associations in the first year of life.
Azad, MB, Konya, T, Guttman, DS, Field, CJ, Sears, MR, HayGlass, KT, Mandhane, PJ, Turvey, SE, Subbarao, P, Becker, AB, Scott, JA, Kozyrskyj, AL, CHILD Study Investigators.
Clin. Exp. Allergy.45,2015. PubMed PMID:25599982

Search PubMed
2014

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
Lewis, JD, Wilton, M, Mott, GA, Lu, W, Hassan, JA, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25546415

Proteomics of effector-triggered immunity (ETI) in plants.
Hurley, B, Subramaniam, R, Guttman, DS, Desveaux, D.
Virulence.5,2014. PubMed PMID:25513776

Peptides and small molecules of the plant-pathogen apoplastic arena.
Mott, GA, Middleton, MA, Desveaux, D, Guttman, DS.
Front Plant Sci.5,2014. PubMed PMID:25506352

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.
Hurley, B, Lee, D, Mott, A, Wilton, M, Liu, J, Liu, YC, Angers, S, Coaker, G, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25503437

Opinion: Conservation and stewardship of the human microbiome.
O'Doherty, KC, Neufeld, JD, Brinkman, FS, Gardner, H, Guttman, DS, Beiko, RG.
Proc. Natl. Acad. Sci. U.S.A.111,2014. PubMed PMID:25294925

Microbial genome-enabled insights into plant-microorganism interactions.
Guttman, DS, McHardy, AC, Schulze-Lefert, P.
Nat. Rev. Genet.15,2014. PubMed PMID:25266034

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.
Belcheva, A, Irrazabal, T, Robertson, SJ, Streutker, C, Maughan, H, Rubino, S, Moriyama, EH, Copeland, JK, Kumar, S, Green, B, Geddes, K, Pezo, RC, Navarre, WW, Milosevic, M, Wilson, BC, Girardin, SE, Wolever, TM, Edelmann, W, Guttman, DS, Philpott, DJ, Martin, A.
Cell.158,2014. PubMed PMID:25036629

Associations between bacterial communities of house dust and infant gut.
Konya, T, Koster, B, Maughan, H, Escobar, M, Azad, MB, Guttman, DS, Sears, MR, Becker, AB, Brook, JR, Takaro, TK, Kozyrskyj, AL, Scott, JA, CHILD Study Investigators.
Environ. Res.131,2014. PubMed PMID:24637181

HopZ4 from Pseudomonas syringae, a member of the HopZ type III effector family from the YopJ superfamily, inhibits the proteasome in plants.
Üstün, S, König, P, Guttman, DS, Börnke, F.
Mol. Plant Microbe Interact.27,2014. PubMed PMID:24625030

The rise of the undead: pseudokinases as mediators of effector-triggered immunity.
Lewis, JD, Lo, T, Bastedo, P, Guttman, DS, Desveaux, D.
Plant Signal Behav.9,2014. PubMed PMID:24398910

Next-generation mapping of genetic mutations using bulk population sequencing.
Austin, RS, Chatfield, SP, Desveaux, D, Guttman, DS.
Methods Mol. Biol.1062,2014. PubMed PMID:24057374

Search PubMed
2013

The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.
Lewis, JD, Lee, AH, Hassan, JA, Wan, J, Hurley, B, Jhingree, JR, Wang, PW, Lo, T, Youn, JY, Guttman, DS, Desveaux, D.
Proc. Natl. Acad. Sci. U.S.A.110,2013. PubMed PMID:24170858

Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis.
Tyler, AD, Knox, N, Kabakchiev, B, Milgrom, R, Kirsch, R, Cohen, Z, McLeod, RS, Guttman, DS, Krause, DO, Silverberg, MS.
PLoS ONE.8,2013. PubMed PMID:24086242

Genomic analysis of the Kiwifruit pathogen Pseudomonas syringae pv. actinidiae provides insight into the origins of an emergent plant disease.
McCann, HC, Rikkerink, EH, Bertels, F, Fiers, M, Lu, A, Rees-George, J, Andersen, MT, Gleave, AP, Haubold, B, Wohlers, MW, Guttman, DS, Wang, PW, Straub, C, Vanneste, JL, Vanneste, J, Rainey, PB, Templeton, MD.
PLoS Pathog.9,2013. PubMed PMID:23935484

Neutral genomic microevolution of a recently emerged pathogen, Salmonella enterica serovar Agona.
Zhou, Z, McCann, A, Litrup, E, Murphy, R, Cormican, M, Fanning, S, Brown, D, Guttman, DS, Brisse, S, Achtman, M.
PLoS Genet.9,2013. PubMed PMID:23637636

Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity.
Azad, MB, Konya, T, Maughan, H, Guttman, DS, Field, CJ, Sears, MR, Becker, AB, Scott, JA, Kozyrskyj, AL.
Allergy Asthma Clin Immunol.9,2013. PubMed PMID:23607879

Phytopathogen type III effectors as probes of biological systems.
Lee, AH, Middleton, MA, Guttman, DS, Desveaux, D.
Microb Biotechnol.6,2013. PubMed PMID:23433088

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad, MB, Konya, T, Maughan, H, Guttman, DS, Field, CJ, Chari, RS, Sears, MR, Becker, AB, Scott, JA, Kozyrskyj, AL, CHILD Study Investigators.
CMAJ.185,2013. PubMed PMID:23401405

Gut microbiota diversity and atopic disease: does breast-feeding play a role?.
Azad, MB, Becker, AB, Guttman, DS, Sears, MR, Scott, JA, Kozyrskyj, AL, Canadian Healthy Infant Longitudinal Development Study Investigators.
J. Allergy Clin. Immunol.131,2013. PubMed PMID:23199602

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2012

Gut microbiota diversity and atopic disease: does breast-feeding play a role?.
Azad, MB, Becker, AB, Guttman, DS, Sears, MR, Scott, JA, Kozyrskyj, AL, Canadian Healthy Infant Longitudinal Development Study Investigators.
J. Allergy Clin. Immunol.131,2013. PubMed PMID:23199602

Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
Schreiber, KJ, Austin, RS, Gong, Y, Zhang, J, Fung, P, Wang, PW, Guttman, DS, Desveaux, D.
BMC Plant Biol.12,2012. PubMed PMID:23176361

Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.
Maughan, H, Wang, PW, Diaz Caballero, J, Fung, P, Gong, Y, Donaldson, SL, Yuan, L, Keshavjee, S, Zhang, Y, Yau, YC, Waters, VJ, Tullis, DE, Hwang, DM, Guttman, DS.
PLoS ONE.7,2012. PubMed PMID:23056217

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Waters, V, Zlosnik, JE, Yau, YC, Speert, DP, Aaron, SD, Guttman, DS.
Eur. J. Clin. Microbiol. Infect. Dis.31,2012. PubMed PMID:22843295

Extensive remodeling of the Pseudomonas syringae pv. avellanae type III secretome associated with two independent host shifts onto hazelnut.
O'Brien, HE, Thakur, S, Gong, Y, Fung, P, Zhang, J, Yuan, L, Wang, PW, Yong, C, Scortichini, M, Guttman, DS.
BMC Microbiol.12,2012. PubMed PMID:22800299

Pseudomonas syringae pv. actinidiae (PSA) isolates from recent bacterial canker of kiwifruit outbreaks belong to the same genetic lineage.
Mazzaglia, A, Studholme, DJ, Taratufolo, MC, Cai, R, Almeida, NF, Goodman, T, Guttman, DS, Vinatzer, BA, Balestra, GM.
PLoS ONE.7,2012. PubMed PMID:22590555

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.
Maughan, H, Cunningham, KS, Wang, PW, Zhang, Y, Cypel, M, Chaparro, C, Tullis, DE, Waddell, TK, Keshavjee, S, Liu, M, Guttman, DS, Hwang, DM.
Pulm Med.2012,2012. PubMed PMID:22448327

Identification of innate immunity elicitors using molecular signatures of natural selection.
McCann, HC, Nahal, H, Thakur, S, Guttman, DS.
Proc. Natl. Acad. Sci. U.S.A.109,2012. PubMed PMID:22323605

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.
Lee, AH, Hurley, B, Felsensteiner, C, Yea, C, Ckurshumova, W, Bartetzko, V, Wang, PW, Quach, V, Lewis, JD, Liu, YC, Börnke, F, Angers, S, Wilde, A, Guttman, DS, Desveaux, D.
PLoS Pathog.8,2012. PubMed PMID:22319451

Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.
Lee, SJ, Lee, J, Li, KK, Holland, D, Maughan, H, Guttman, DS, Yusta, B, Drucker, DJ.
Endocrinology.153,2012. PubMed PMID:22253424

Quantitative Interactor Screening with next-generation Sequencing (QIS-Seq) identifies Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2.
Lewis, JD, Wan, J, Ford, R, Gong, Y, Fung, P, Nahal, H, Wang, PW, Desveaux, D, Guttman, DS.
BMC Genomics.13,2012. PubMed PMID:22230763

E622, a miniature, virulence-associated mobile element.
Stavrinides, J, Kirzinger, MW, Beasley, FC, Guttman, DS.
J. Bacteriol.194,2012. PubMed PMID:22081398

HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens.
Sohn, KH, Saucet, SB, Clarke, CR, Vinatzer, BA, O'Brien, HE, Guttman, DS, Jones, JD.
New Phytol.193,2012. PubMed PMID:22053875

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2011

E622, a miniature, virulence-associated mobile element.
Stavrinides, J, Kirzinger, MW, Beasley, FC, Guttman, DS.
J. Bacteriol.194,2012. PubMed PMID:22081398

Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.
O'Brien, HE, Gong, Y, Fung, P, Wang, PW, Guttman, DS.
PLoS ONE.6,2011. PubMed PMID:22073286

HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens.
Sohn, KH, Saucet, SB, Clarke, CR, Vinatzer, BA, O'Brien, HE, Guttman, DS, Jones, JD.
New Phytol.193,2012. PubMed PMID:22053875

Tri6 is a global transcription regulator in the phytopathogen Fusarium graminearum.
Nasmith, CG, Walkowiak, S, Wang, L, Leung, WW, Gong, Y, Johnston, A, Harris, LJ, Guttman, DS, Subramaniam, R.
PLoS Pathog.7,2011. PubMed PMID:21980289

The YopJ superfamily in plant-associated bacteria.
Lewis, JD, Lee, A, Ma, W, Zhou, H, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.12,2011. PubMed PMID:21726386

Evolution of plant pathogenesis in Pseudomonas syringae: a genomics perspective.
O'Brien, HE, Thakur, S, Guttman, DS.
Annu Rev Phytopathol.49,2011. PubMed PMID:21568703

Next-generation mapping of Arabidopsis genes.
Austin, RS, Vidaurre, D, Stamatiou, G, Breit, R, Provart, NJ, Bonetta, D, Zhang, J, Fung, P, Gong, Y, Wang, PW, McCourt, P, Guttman, DS.
Plant J.67,2011. PubMed PMID:21518053

Transcriptomic responses of the softwood-degrading white-rot fungus Phanerochaete carnosa during growth on coniferous and deciduous wood.
MacDonald, J, Doering, M, Canam, T, Gong, Y, Guttman, DS, Campbell, MM, Master, ER.
Appl. Environ. Microbiol.77,2011. PubMed PMID:21441342

Next-generation genomics of Pseudomonas syringae.
O'Brien, HE, Desveaux, D, Guttman, DS.
Curr. Opin. Microbiol.14,2011. PubMed PMID:21233007

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2010

Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations.
Anderson, JB, Funt, J, Thompson, DA, Prabhu, S, Socha, A, Sirjusingh, C, Dettman, JR, Parreiras, L, Guttman, DS, Regev, A, Kohn, LM.
Curr. Biol.20,2010. PubMed PMID:20637622

Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein.
Lewis, JD, Wu, R, Guttman, DS, Desveaux, D.
PLoS Genet.6,2010. PubMed PMID:20368970

PAMDB, a multilocus sequence typing and analysis database and website for plant-associated microbes.
Almeida, NF, Yan, S, Cai, R, Clarke, CR, Morris, CE, Schaad, NW, Schuenzel, EL, Lacy, GH, Sun, X, Jones, JB, Castillo, JA, Bull, CT, Leman, S, Guttman, DS, Setubal, JC, Vinatzer, BA.
Phytopathology.100,2010. PubMed PMID:20128693

Pseudomonas syringae strains naturally lacking the classical P. syringae hrp/hrc Locus are common leaf colonizers equipped with an atypical type III secretion system.
Clarke, CR, Cai, R, Studholme, DJ, Guttman, DS, Vinatzer, BA.
Mol. Plant Microbe Interact.23,2010. PubMed PMID:20064063

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2009

Bacterial evolution: dynamic genomes and the power of transformation.
Guttman, DS.
Curr. Biol.19,2009. PubMed PMID:19788881

The targeting of plant cellular systems by injected type III effector proteins.
Lewis, JD, Guttman, DS, Desveaux, D.
Semin. Cell Dev. Biol.20,2009. PubMed PMID:19540926

Using a commercial DiversiLab semiautomated repetitive sequence-based PCR typing technique for identification of Escherichia coli clone ST131 producing CTX-M-15.
Pitout, JD, Campbell, L, Church, DL, Wang, PW, Guttman, DS, Gregson, DB.
J. Clin. Microbiol.47,2009. PubMed PMID:19204095

Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems.
Zhou, H, Morgan, RL, Guttman, DS, Ma, W.
Mol. Plant Microbe Interact.22,2009. PubMed PMID:19132870

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2008

A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass.
Singh, S, Stavrinides, J, Christendat, D, Guttman, DS.
Mol. Biol. Evol.25,2008. PubMed PMID:18669580

Evolution of prokaryotic and eukaryotic virulence effectors.
Ma, W, Guttman, DS.
Curr. Opin. Plant Biol.11,2008. PubMed PMID:18585954

New and sensitive assay for determining Pseudomonas aeruginosa metallo-beta-lactamase resistance to imipenem.
Tan, J, Pitout, JD, Guttman, DS.
J. Clin. Microbiol.46,2008. PubMed PMID:18337388

The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thaliana.
Lewis, JD, Abada, W, Ma, W, Guttman, DS, Desveaux, D.
J. Bacteriol.190,2008. PubMed PMID:18263728

Evolution of the type III secretion system and its effectors in plant-microbe interactions.
McCann, HC, Guttman, DS.
New Phytol.177,2008. PubMed PMID:18078471

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865

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2007

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865

Convergent evolution of phytopathogenic pseudomonads onto hazelnut.
Wang, PW, Morgan, RL, Scortichini, M, Guttman, DS.
Microbiology (Reading, Engl.).153,2007. PubMed PMID:17600051

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2006

Type III effector diversification via both pathoadaptation and horizontal transfer in response to a coevolutionary arms race.
Ma, W, Dong, FF, Stavrinides, J, Guttman, DS.
PLoS Genet.2,2006. PubMed PMID:17194219

Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Vencato, M, Tian, F, Alfano, JR, Buell, CR, Cartinhour, S, DeClerck, GA, Guttman, DS, Stavrinides, J, Joardar, V, Lindeberg, M, Bronstein, PA, Mansfield, JW, Myers, CR, Collmer, A, Schneider, DJ.
Mol. Plant Microbe Interact.19,2006. PubMed PMID:17073302

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens.
Stavrinides, J, Ma, W, Guttman, DS.
PLoS Pathog.2,2006. PubMed PMID:17040127

Comparative genomics of host-specific virulence in Pseudomonas syringae.
Sarkar, SF, Gordon, JS, Martin, GB, Guttman, DS.
Genetics.174,2006. PubMed PMID:16951068

Diversifying selection drives the evolution of the type III secretion system pilus of Pseudomonas syringae.
Guttman, DS, Gropp, SJ, Morgan, RL, Wang, PW.
Mol. Biol. Evol.23,2006. PubMed PMID:16950758

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2005

Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae.
Hwang, MS, Morgan, RL, Sarkar, SF, Wang, PW, Guttman, DS.
Appl. Environ. Microbiol.71,2005. PubMed PMID:16151103

Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae.
Lindeberg, M, Stavrinides, J, Chang, JH, Alfano, JR, Collmer, A, Dangl, JL, Greenberg, JT, Mansfield, JW, Guttman, DS.
Mol. Plant Microbe Interact.18,2005. PubMed PMID:15828679

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2004

Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringae.
Rohmer, L, Guttman, DS, Dangl, JL.
Genetics.167,2004. PubMed PMID:15280247

Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.
Stavrinides, J, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:15262947

Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.
Sarkar, SF, Guttman, DS.
Appl. Environ. Microbiol.70,2004. PubMed PMID:15066790

Plants as models for the study of human pathogenesis.
Guttman, DS.
Biotechnol. Adv.22,2004. PubMed PMID:15063457

The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.
Gropp, SJ, Guttman, DS.
Mol. Plant Pathol.5,2004. PubMed PMID:20565590

Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.
Wang, PW, Chu, L, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:14702309

Mosaic evolution of the severe acute respiratory syndrome coronavirus.
Stavrinides, J, Guttman, DS.
J. Virol.78,2004. PubMed PMID:14671089

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2003

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2002

A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.
Guttman, DS, Vinatzer, BA, Sarkar, SF, Ranall, MV, Kettler, G, Greenberg, JT.
Science.295,2002. PubMed PMID:11872842

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2001

Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system.
Guttman, DS, Greenberg, JT.
Mol. Plant Microbe Interact.14,2001. PubMed PMID:11204777

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2000

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Earlier Publications

The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth.
Rate, DN, Cuenca, JV, Bowman, GR, Guttman, DS, Greenberg, JT.
Plant Cell.11,1999. PubMed PMID:10488236

An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.
Guttman, DS, Charlesworth, D.
Nature.393,1998. PubMed PMID:9607762

Lack of degeneration of loci on the neo-Y chromosome of Drosophila americana americana.
Charlesworth, B, Charlesworth, D, Hnilicka, J, Yu, A, Guttman, DS.
Genetics.145,1997. PubMed PMID:9093852

Recombination and clonality in natural populations of Escherichia coli.
Guttman, DS.
Trends Ecol. Evol. (Amst.).12,1997. PubMed PMID:21237956

Seeing selection in S allele sequences.
Charlesworth, D, Guttman, DS.
Curr. Biol.7,1997. PubMed PMID:9072167

Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Guttman, DS, Wang, PW, Wang, IN, Bosler, EM, Luft, BJ, Dykhuizen, DE.
J. Clin. Microbiol.34,1996. PubMed PMID:8904432

Detecting selective sweeps in naturally occurring Escherichia coli.
Guttman, DS, Dykhuizen, DE.
Genetics.138,1994. PubMed PMID:7896119

Clonal divergence in Escherichia coli as a result of recombination, not mutation.
Guttman, DS, Dykhuizen, DE.
Science.266,1994. PubMed PMID:7973728

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