Mehdi Layeghifard, PhD.
Postdoctoral Fellow
Publications:
SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma.
Valencia-Sama, I, Kee, L, Christopher, G, Ohh, M, Layeghifard, M, Shlien, A, Hayes, MN, Irwin, MS.
Cancer Res Commun.3,2023. PubMed PMID:38032104
BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma.
Randall, MP, Egolf, LE, Vaksman, Z, Samanta, M, Tsang, M, Groff, D, Evans, JP, Rokita, JL, Layeghifard, M, Shlien, A, Maris, JM, Diskin, SJ, Bosse, KR.
J Natl Cancer Inst.116,2024. PubMed PMID:37688570
BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma.
Randall, MP, Egolf, LE, Vaksman, Z, Samanta, M, Tsang, M, Groff, D, Evans, JP, Rokita, JL, Layeghifard, M, Shlien, A, Maris, JM, Diskin, SJ, Bosse, KR.
bioRxiv.,2023. PubMed PMID:36778420
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.
Light, N, Layeghifard, M, Attery, A, Subasri, V, Zatzman, M, Anderson, ND, Hatkar, R, Blay, S, Chen, D, Novokmet, A, Fuligni, F, Tran, J, de Borja, R, Agarwal, H, Waldman, L, Abegglen, LM, Albertson, D, Finlay, JL, Hansford, JR, Behjati, S, Villani, A, Gerstung, M, Alexandrov, LB, Somers, GR, Schiffman, JD, Rotter, V, Malkin, D, Shlien, A.
Nat Commun.14,2023. PubMed PMID:36604421
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.
Villani, A, Davidson, S, Kanwar, N, Lo, WW, Li, Y, Cohen-Gogo, S, Fuligni, F, Edward, LM, Light, N, Layeghifard, M, Harripaul, R, Waldman, L, Gallinger, B, Comitani, F, Brunga, L, Hayes, R, Anderson, ND, Ramani, AK, Yuki, KE, Blay, S, Johnstone, B, Inglese, C, Hammad, R, Goudie, C, Shuen, A, Wasserman, JD, Venier, RE, Eliou, M, Lorenti, M, Ryan, CA, Braga, M, Gloven-Brown, M, Han, J, Montero, M, Spatare, F, Whitlock, JA, Scherer, SW, Chun, K, Somerville, MJ, Hawkins, C, Abdelhaleem, M, Ramaswamy, V, Somers, GR, Kyriakopoulou, L, Hitzler, J, Shago, M, Morgenstern, DA, Tabori, U, Meyn, S, Irwin, MS, Malkin, D, Shlien, A.
Nat Cancer.4,2023. PubMed PMID:36585449
Identification of a differential metabolite-based signature in patients with late-stage knee osteoarthritis.
Rockel, JS, Layeghifard, M, Rampersaud, YR, Perruccio, AV, Mahomed, NN, Davey, JR, Syed, K, Gandhi, R, Kapoor, M.
Osteoarthr Cartil Open.4,2022. PubMed PMID:36474953
Association of presurgical circulating MicroRNAs with 1-year postsurgical pain reduction in spine facet osteoarthritis patients with lumbar spinal stenosis.
Lively, S, Milliot, M, Potla, P, Espin-Garcia, O, Layeghifard, M, Sundararajan, K, Endisha, H, Nakamura, A, Perruccio, AV, Veillette, C, Kapoor, M, Rampersaud, YR.
Osteoarthr Cartil Open.4,2022. PubMed PMID:36474943
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.
Anderson, ND, Babichev, Y, Fuligni, F, Comitani, F, Layeghifard, M, Venier, RE, Dentro, SC, Maheshwari, A, Guram, S, Wunker, C, Thompson, JD, Yuki, KE, Hou, H, Zatzman, M, Light, N, Bernardini, MQ, Wunder, JS, Andrulis, IL, Ferguson, P, Razak, ARA, Swallow, CJ, Dowling, JJ, Al-Awar, RS, Marcellus, R, Rouzbahman, M, Gerstung, M, Durocher, D, Alexandrov, LB, Dickson, BC, Gladdy, RA, Shlien, A.
Nat Commun.12,2021. PubMed PMID:34301934
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.
Nakamori, M, Panigrahi, GB, Lanni, S, Gall-Duncan, T, Hayakawa, H, Tanaka, H, Luo, J, Otabe, T, Li, J, Sakata, A, Caron, MC, Joshi, N, Prasolava, T, Chiang, K, Masson, JY, Wold, MS, Wang, X, Lee, MYWT, Huddleston, J, Munson, KM, Davidson, S, Layeghifard, M, Edward, LM, Gallon, R, Santibanez-Koref, M, Murata, A, Takahashi, MP, Eichler, EE, Shlien, A, Nakatani, K, Mochizuki, H, Pearson, CE.
Nat Genet.52,2020. PubMed PMID:32060489
Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.
Layeghifard, M, Li, H, Wang, PW, Donaldson, SL, Coburn, B, Clark, ST, Caballero, JD, Zhang, Y, Tullis, DE, Yau, YCW, Waters, V, Hwang, DM, Guttman, DS.
NPJ Biofilms Microbiomes.5,2019. PubMed PMID:30675371
Constructing and Analyzing Microbiome Networks in R.
Layeghifard, M, Hwang, DM, Guttman, DS.
Methods Mol Biol.1849,2018. PubMed PMID:30298259
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
Anderson, ND, de Borja, R, Young, MD, Fuligni, F, Rosic, A, Roberts, ND, Hajjar, S, Layeghifard, M, Novokmet, A, Kowalski, PE, Anaka, M, Davidson, S, Zarrei, M, Id Said, B, Schreiner, LC, Marchand, R, Sitter, J, Gokgoz, N, Brunga, L, Graham, GT, Fullam, A, Pillay, N, Toretsky, JA, Yoshida, A, Shibata, T, Metzler, M, Somers, GR, Scherer, SW, Flanagan, AM, Campbell, PJ, Schiffman, JD, Shago, M, Alexandrov, LB, Wunder, JS, Andrulis, IL, Malkin, D, Behjati, S, Shlien, A.
Science.361,2018. PubMed PMID:30166462
Publisher Correction: An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Smakowska-Luzan, E, Mott, GA, Parys, K, Stegmann, M, Howton, TC, Layeghifard, M, Neuhold, J, Lehner, A, Kong, J, Grünwald, K, Weinberger, N, Satbhai, SB, Mayer, D, Busch, W, Madalinski, M, Stolt-Bergner, P, Provart, NJ, Mukhtar, MS, Zipfel, C, Desveaux, D, Guttman, DS, Belkhadir, Y.
Nature.561,2018. PubMed PMID:29973716
Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population.
Middleton, MA, Layeghifard, M, Klingel, M, Stanojevic, S, Yau, YCW, Zlosnik, JEA, Coriati, A, Ratjen, FA, Tullis, ED, Stephenson, A, Wilcox, P, Freitag, A, Chilvers, M, McKinney, M, Lavoie, A, Wang, PW, Guttman, DS, Waters, VJ.
Ann Am Thorac Soc.15,2018. PubMed PMID:29911888
An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Smakowska-Luzan, E, Mott, GA, Parys, K, Stegmann, M, Howton, TC, Layeghifard, M, Neuhold, J, Lehner, A, Kong, J, Grünwald, K, Weinberger, N, Satbhai, SB, Mayer, D, Busch, W, Madalinski, M, Stolt-Bergner, P, Provart, NJ, Mukhtar, MS, Zipfel, C, Desveaux, D, Guttman, DS, Belkhadir, Y.
Nature.553,2018. PubMed PMID:29320478
Disentangling Interactions in the Microbiome: A Network Perspective.
Layeghifard, M, Hwang, DM, Guttman, DS.
Trends Microbiol.25,2017. PubMed PMID:27916383
Seasonal community succession of the phyllosphere microbiome.
Copeland, JK, Yuan, L, Layeghifard, M, Wang, PW, Guttman, DS.
Mol Plant Microbe Interact.28,2015. PubMed PMID:25679538
Inferring explicit weighted consensus networks to represent alternative evolutionary histories.
Layeghifard, M, Peres-Neto, PR, Makarenkov, V.
BMC Evol Biol.13,2013. PubMed PMID:24359207
Using directed phylogenetic networks to retrace species dispersal history.
Layeghifard, M, Peres-Neto, PR, Makarenkov, V.
Mol Phylogenet Evol.64,2012. PubMed PMID:22491069
Evolutionary mechanisms underlying the functional divergence of duplicate genes involved in vertebrates' circadian rhythm pathway.
Layeghifard, M, Rabani, R, Pirhaji, L, Yakhchali, B.
Gene.426,2008. PubMed PMID:18804153