Shawn Clark
Postdoctoral Fellow
Ph.D. University of Toronto, 2018
Lab: ESC 4039
Email: shawn.clark@mail.utoronto.ca
Publications:
Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.
Layeghifard M, Li H, Wang PW, Donaldson SL, Coburn B, Clark ST, Caballero JD, Zhang Y, Tullis DE, Yau YCW, Waters V, Hwang DM, Guttman DS.
NPJ Biofilms Microbiomes. 2019 Jan 21;5:4. doi: 10.1038/s41522-018-0077-y. eCollection 2019.
PMID: 30675371
Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.
Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM.
Int J Antimicrob Agents. 2019 May;53(5):620-628. doi: 10.1016/j.ijantimicag.2019.01.009. Epub 2019 Jan 19.
PMID: 30664925
A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.
Diaz Caballero J, Clark ST, Wang PW, Donaldson SL, Coburn B, Tullis DE, Yau YCW, Waters VJ, Hwang DM, Guttman DS.
PLoS Pathog. 2018 Dec 7;14(12):e1007453. doi: 10.1371/journal.ppat.1007453. eCollection 2018 Dec.
PMID: 30532201
Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance.
Clark ST, Guttman DS, Hwang DM.
FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny026.
PMID: 29401362
Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
Kim SH, Clark ST, Surendra A, Copeland JK, Wang PW, Ammar R, Collins C, Tullis DE, Nislow C, Hwang DM, Guttman DS, Cowen LE.
PLoS Pathog. 2015 Nov 20;11(11):e1005308. doi: 10.1371/journal.ppat.1005308. eCollection 2015 Nov.
PMID: 26588216
Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
Diaz Caballero J, Clark ST, Coburn B, Zhang Y, Wang PW, Donaldson SL, Tullis DE, Yau YC, Waters VJ, Hwang DM, Guttman DS.
MBio. 2015 Sep 1;6(5):e00981-15. doi: 10.1128/mBio.00981-15.
PMID: 26330513
Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
Clark ST, Diaz Caballero J, Cheang M, Coburn B, Wang PW, Donaldson SL, Zhang Y, Liu M, Keshavjee S, Yau YC, Waters VJ, Elizabeth Tullis D, Guttman DS, Hwang DM.
Sci Rep. 2015 Jun 5;5:10932. doi: 10.1038/srep10932.
PMID: 26047320
Lung microbiota across age and disease stage in cystic fibrosis.
Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S, Zhang Y, Surendra A, Gong Y, Elizabeth Tullis D, Yau YC, Waters VJ, Hwang DM, Guttman DS.
Sci Rep. 2015 May 14;5:10241. doi: 10.1038/srep10241.
PMID: 25974282