Publications

2018
An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Smakowska-Luzan, E, Mott, GA, Parys, K, Stegmann, M, Howton, TC, Layeghifard, M, Neuhold, J, Lehner, A, Kong, J, Grünwald, K, Weinberger, N, Satbhai, SB, Mayer, D, Busch, W, Madalinski, M, Stolt-Bergner, P, Provart, NJ, Mukhtar, MS, Zipfel, C, Desveaux, D, Guttman, DS, Belkhadir, Y.
Nature.553,2018. PubMed PMID:29320478
2017
Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases.
Seto, D, Koulena, N, Lo, T, Menna, A, Guttman, DS, Desveaux, D.
Nat Plants.3,2017. PubMed PMID:28288096

Disentangling Interactions in the Microbiome: A Network Perspective.
Layeghifard, M, Hwang, DM, Guttman, DS.
Trends Microbiol.25,2017. PubMed PMID:27916383

Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.
Baltrus, DA, McCann, HC, Guttman, DS.
Mol. Plant Pathol.18,2017. PubMed PMID:27798954

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo, T, Koulena, N, Seto, D, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.18,2017. PubMed PMID:27061875
2016
Image-Based Quantification of Plant Immunity and Disease.
Laflamme, B, Middleton, M, Lo, T, Desveaux, D, Guttman, DS.
Mol. Plant Microbe Interact.,2016. PubMed PMID:27996374

Disentangling Interactions in the Microbiome: A Network Perspective.
Layeghifard, M, Hwang, DM, Guttman, DS.
Trends Microbiol.,2016. PubMed PMID:27916383

Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.
Baltrus, DA, McCann, HC, Guttman, DS.
Mol. Plant Pathol.18,2017. PubMed PMID:27798954

Association of host genome with intestinal microbial composition in a large healthy cohort.
Turpin, W, Espin-Garcia, O, Xu, W, Silverberg, MS, Kevans, D, Smith, MI, Guttman, DS, Griffiths, A, Panaccione, R, Otley, A, Xu, L, Shestopaloff, K, Moreno-Hagelsieb, G, GEM Project Research Consortium, Paterson, AD, Croitoru, K.
Nat. Genet.48,2016. PubMed PMID:27694960

Gene Slider: sequence logo interactive data-visualization for education and research.
Waese, J, Pasha, A, Wang, TT, van Weringh, A, Guttman, DS, Provart, NJ.
Bioinformatics.32,2016. PubMed PMID:27522081

A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.
Thakur, S, Guttman, DS.
BMC Bioinformatics.17,2016. PubMed PMID:27363390

Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.
Mott, GA, Thakur, S, Smakowska, E, Wang, PW, Belkhadir, Y, Desveaux, D, Guttman, DS.
Genome Biol.17,2016. PubMed PMID:27160854

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo, T, Koulena, N, Seto, D, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.,2016. PubMed PMID:27061875

Phytopathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae Type and Pathotype Strains.
Thakur, S, Weir, BS, Guttman, DS.
Mol. Plant Microbe Interact.29,2016. PubMed PMID:26883489
2015
Elevated Temperature Differentially Influences Effector-Triggered Immunity Outputs in Arabidopsis.
Menna, A, Nguyen, D, Guttman, DS, Desveaux, D.
Front Plant Sci.6,2015. PubMed PMID:26617631

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
Kim, SH, Clark, ST, Surendra, A, Copeland, JK, Wang, PW, Ammar, R, Collins, C, Tullis, DE, Nislow, C, Hwang, DM, Guttman, DS, Cowen, LE.
PLoS Pathog.11,2015. PubMed PMID:26588216

Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
Diaz Caballero, J, Clark, ST, Coburn, B, Zhang, Y, Wang, PW, Donaldson, SL, Tullis, DE, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
MBio.6,2015. PubMed PMID:26330513

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
Clark, ST, Diaz Caballero, J, Cheang, M, Coburn, B, Wang, PW, Donaldson, SL, Zhang, Y, Liu, M, Keshavjee, S, Yau, YC, Waters, VJ, Elizabeth Tullis, D, Guttman, DS, Hwang, DM.
Sci Rep.5,2015. PubMed PMID:26047320

The human microbiome.
Coburn, B, Guttman, DS.
CMAJ.187,2015. PubMed PMID:25991836

Lung microbiota across age and disease stage in cystic fibrosis.
Coburn, B, Wang, PW, Diaz Caballero, J, Clark, ST, Brahma, V, Donaldson, S, Zhang, Y, Surendra, A, Gong, Y, Elizabeth Tullis, D, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
Sci Rep.5,2015. PubMed PMID:25974282

Seasonal community succession of the phyllosphere microbiome.
Copeland, JK, Yuan, L, Layeghifard, M, Wang, PW, Guttman, DS.
Mol. Plant Microbe Interact.28,2015. PubMed PMID:25679538
2014
Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
Lewis, JD, Wilton, M, Mott, GA, Lu, W, Hassan, JA, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25546415

Proteomics of effector-triggered immunity (ETI) in plants.
Hurley, B, Subramaniam, R, Guttman, DS, Desveaux, D.
Virulence.5,2014. PubMed PMID:25513776

Peptides and small molecules of the plant-pathogen apoplastic arena.
Mott, GA, Middleton, MA, Desveaux, D, Guttman, DS.
Front Plant Sci.5,2014. PubMed PMID:25506352

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.
Hurley, B, Lee, D, Mott, A, Wilton, M, Liu, J, Liu, YC, Angers, S, Coaker, G, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25503437

Opinion: Conservation and stewardship of the human microbiome.
O'Doherty, KC, Neufeld, JD, Brinkman, FS, Gardner, H, Guttman, DS, Beiko, RG.
Proc. Natl. Acad. Sci. U.S.A.111,2014. PubMed PMID:25294925

Microbial genome-enabled insights into plant-microorganism interactions.
Guttman, DS, McHardy, AC, Schulze-Lefert, P.
Nat. Rev. Genet.15,2014. PubMed PMID:25266034

The rise of the undead: pseudokinases as mediators of effector-triggered immunity.
Lewis, JD, Lo, T, Bastedo, P, Guttman, DS, Desveaux, D.
Plant Signal Behav.9,2014. PubMed PMID:24398910

Next-generation mapping of genetic mutations using bulk population sequencing.
Austin, RS, Chatfield, SP, Desveaux, D, Guttman, DS.
Methods Mol. Biol.1062,2014. PubMed PMID:24057374
2013
The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.
Lewis, JD, Lee, AH, Hassan, JA, Wan, J, Hurley, B, Jhingree, JR, Wang, PW, Lo, T, Youn, JY, Guttman, DS, Desveaux, D.
Proc. Natl. Acad. Sci. U.S.A.110,2013. PubMed PMID:24170858

Phytopathogen type III effectors as probes of biological systems.
Lee, AH, Middleton, MA, Guttman, DS, Desveaux, D.
Microb Biotechnol.6,2013. PubMed PMID:23433088
2012
Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
Schreiber, KJ, Austin, RS, Gong, Y, Zhang, J, Fung, P, Wang, PW, Guttman, DS, Desveaux, D.
BMC Plant Biol.12,2012. PubMed PMID:23176361

Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.
Maughan, H, Wang, PW, Diaz Caballero, J, Fung, P, Gong, Y, Donaldson, SL, Yuan, L, Keshavjee, S, Zhang, Y, Yau, YC, Waters, VJ, Tullis, DE, Hwang, DM, Guttman, DS.
PLoS ONE.7,2012. PubMed PMID:23056217

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Waters, V, Zlosnik, JE, Yau, YC, Speert, DP, Aaron, SD, Guttman, DS.
Eur. J. Clin. Microbiol. Infect. Dis.31,2012. PubMed PMID:22843295

Extensive remodeling of the Pseudomonas syringae pv. avellanae type III secretome associated with two independent host shifts onto hazelnut.
O'Brien, HE, Thakur, S, Gong, Y, Fung, P, Zhang, J, Yuan, L, Wang, PW, Yong, C, Scortichini, M, Guttman, DS.
BMC Microbiol.12,2012. PubMed PMID:22800299

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.
Maughan, H, Cunningham, KS, Wang, PW, Zhang, Y, Cypel, M, Chaparro, C, Tullis, DE, Waddell, TK, Keshavjee, S, Liu, M, Guttman, DS, Hwang, DM.
Pulm Med.2012,2012. PubMed PMID:22448327

Identification of innate immunity elicitors using molecular signatures of natural selection.
McCann, HC, Nahal, H, Thakur, S, Guttman, DS.
Proc. Natl. Acad. Sci. U.S.A.109,2012. PubMed PMID:22323605

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.
Lee, AH, Hurley, B, Felsensteiner, C, Yea, C, Ckurshumova, W, Bartetzko, V, Wang, PW, Quach, V, Lewis, JD, Liu, YC, Börnke, F, Angers, S, Wilde, A, Guttman, DS, Desveaux, D.
PLoS Pathog.8,2012. PubMed PMID:22319451

Quantitative Interactor Screening with next-generation Sequencing (QIS-Seq) identifies Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2.
Lewis, JD, Wan, J, Ford, R, Gong, Y, Fung, P, Nahal, H, Wang, PW, Desveaux, D, Guttman, DS.
BMC Genomics.13,2012. PubMed PMID:22230763

E622, a miniature, virulence-associated mobile element.
Stavrinides, J, Kirzinger, MW, Beasley, FC, Guttman, DS.
J. Bacteriol.194,2012. PubMed PMID:22081398
2011
Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.
O'Brien, HE, Gong, Y, Fung, P, Wang, PW, Guttman, DS.
PLoS ONE.6,2011. PubMed PMID:22073286

The YopJ superfamily in plant-associated bacteria.
Lewis, JD, Lee, A, Ma, W, Zhou, H, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.12,2011. PubMed PMID:21726386

Evolution of plant pathogenesis in Pseudomonas syringae: a genomics perspective.
O'Brien, HE, Thakur, S, Guttman, DS.
Annu Rev Phytopathol.49,2011. PubMed PMID:21568703

Next-generation mapping of Arabidopsis genes.
Austin, RS, Vidaurre, D, Stamatiou, G, Breit, R, Provart, NJ, Bonetta, D, Zhang, J, Fung, P, Gong, Y, Wang, PW, McCourt, P, Guttman, DS.
Plant J.67,2011. PubMed PMID:21518053

Next-generation genomics of Pseudomonas syringae.
O'Brien, HE, Desveaux, D, Guttman, DS.
Curr. Opin. Microbiol.14,2011. PubMed PMID:21233007
2010
Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein.
Lewis, JD, Wu, R, Guttman, DS, Desveaux, D.
PLoS Genet.6,2010. PubMed PMID:20368970
2009
Bacterial evolution: dynamic genomes and the power of transformation.
Guttman, DS.
Curr. Biol.19,2009. PubMed PMID:19788881

The targeting of plant cellular systems by injected type III effector proteins.
Lewis, JD, Guttman, DS, Desveaux, D.
Semin. Cell Dev. Biol.20,2009. PubMed PMID:19540926

Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems.
Zhou, H, Morgan, RL, Guttman, DS, Ma, W.
Mol. Plant Microbe Interact.22,2009. PubMed PMID:19132870
2008
Evolution of prokaryotic and eukaryotic virulence effectors.
Ma, W, Guttman, DS.
Curr. Opin. Plant Biol.11,2008. PubMed PMID:18585954

New and sensitive assay for determining Pseudomonas aeruginosa metallo-beta-lactamase resistance to imipenem.
Tan, J, Pitout, JD, Guttman, DS.
J. Clin. Microbiol.46,2008. PubMed PMID:18337388

The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thaliana.
Lewis, JD, Abada, W, Ma, W, Guttman, DS, Desveaux, D.
J. Bacteriol.190,2008. PubMed PMID:18263728

Evolution of the type III secretion system and its effectors in plant-microbe interactions.
McCann, HC, Guttman, DS.
New Phytol.177,2008. PubMed PMID:18078471

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865
2007
Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865

Convergent evolution of phytopathogenic pseudomonads onto hazelnut.
Wang, PW, Morgan, RL, Scortichini, M, Guttman, DS.
Microbiology (Reading, Engl.).153,2007. PubMed PMID:17600051
2006
Type III effector diversification via both pathoadaptation and horizontal transfer in response to a coevolutionary arms race.
Ma, W, Dong, FF, Stavrinides, J, Guttman, DS.
PLoS Genet.2,2006. PubMed PMID:17194219

Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Vencato, M, Tian, F, Alfano, JR, Buell, CR, Cartinhour, S, DeClerck, GA, Guttman, DS, Stavrinides, J, Joardar, V, Lindeberg, M, Bronstein, PA, Mansfield, JW, Myers, CR, Collmer, A, Schneider, DJ.
Mol. Plant Microbe Interact.19,2006. PubMed PMID:17073302

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens.
Stavrinides, J, Ma, W, Guttman, DS.
PLoS Pathog.2,2006. PubMed PMID:17040127

Comparative genomics of host-specific virulence in Pseudomonas syringae.
Sarkar, SF, Gordon, JS, Martin, GB, Guttman, DS.
Genetics.174,2006. PubMed PMID:16951068

Diversifying selection drives the evolution of the type III secretion system pilus of Pseudomonas syringae.
Guttman, DS, Gropp, SJ, Morgan, RL, Wang, PW.
Mol. Biol. Evol.23,2006. PubMed PMID:16950758
2005
Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae.
Hwang, MS, Morgan, RL, Sarkar, SF, Wang, PW, Guttman, DS.
Appl. Environ. Microbiol.71,2005. PubMed PMID:16151103

Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae.
Lindeberg, M, Stavrinides, J, Chang, JH, Alfano, JR, Collmer, A, Dangl, JL, Greenberg, JT, Mansfield, JW, Guttman, DS.
Mol. Plant Microbe Interact.18,2005. PubMed PMID:15828679
2004
Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringae.
Rohmer, L, Guttman, DS, Dangl, JL.
Genetics.167,2004. PubMed PMID:15280247

Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.
Stavrinides, J, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:15262947

Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.
Sarkar, SF, Guttman, DS.
Appl. Environ. Microbiol.70,2004. PubMed PMID:15066790

Plants as models for the study of human pathogenesis.
Guttman, DS.
Biotechnol. Adv.22,2004. PubMed PMID:15063457

The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.
Gropp, SJ, Guttman, DS.
Mol. Plant Pathol.5,2004. PubMed PMID:20565590

Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.
Wang, PW, Chu, L, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:14702309

Mosaic evolution of the severe acute respiratory syndrome coronavirus.
Stavrinides, J, Guttman, DS.
J. Virol.78,2004. PubMed PMID:14671089
2002
A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.
Guttman, DS, Vinatzer, BA, Sarkar, SF, Ranall, MV, Kettler, G, Greenberg, JT.
Science.295,2002. PubMed PMID:11872842
2001
Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system.
Guttman, DS, Greenberg, JT.
Mol. Plant Microbe Interact.14,2001. PubMed PMID:11204777
Earlier Publications
An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.
Guttman, DS, Charlesworth, D.
Nature.393,1998. PubMed PMID:9607762

Recombination and clonality in natural populations of Escherichia coli.
Guttman, DS.
Trends Ecol. Evol. (Amst.).12,1997. PubMed PMID:21237956

Seeing selection in S allele sequences.
Charlesworth, D, Guttman, DS.
Curr. Biol.7,1997. PubMed PMID:9072167

Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Guttman, DS, Wang, PW, Wang, IN, Bosler, EM, Luft, BJ, Dykhuizen, DE.
J. Clin. Microbiol.34,1996. PubMed PMID:8904432

Detecting selective sweeps in naturally occurring Escherichia coli.
Guttman, DS, Dykhuizen, DE.
Genetics.138,1994. PubMed PMID:7896119

Clonal divergence in Escherichia coli as a result of recombination, not mutation.
Guttman, DS, Dykhuizen, DE.
Science.266,1994. PubMed PMID:7973728

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Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system.
Guttman, DS, Greenberg, JT.
Mol. Plant Microbe Interact.14,2001. PubMed PMID:11204777

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2000

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Earlier Publications

The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth.
Rate, DN, Cuenca, JV, Bowman, GR, Guttman, DS, Greenberg, JT.
Plant Cell.11,1999. PubMed PMID:10488236

An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.
Guttman, DS, Charlesworth, D.
Nature.393,1998. PubMed PMID:9607762

Lack of degeneration of loci on the neo-Y chromosome of Drosophila americana americana.
Charlesworth, B, Charlesworth, D, Hnilicka, J, Yu, A, Guttman, DS.
Genetics.145,1997. PubMed PMID:9093852

Recombination and clonality in natural populations of Escherichia coli.
Guttman, DS.
Trends Ecol. Evol. (Amst.).12,1997. PubMed PMID:21237956

Seeing selection in S allele sequences.
Charlesworth, D, Guttman, DS.
Curr. Biol.7,1997. PubMed PMID:9072167

Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Guttman, DS, Wang, PW, Wang, IN, Bosler, EM, Luft, BJ, Dykhuizen, DE.
J. Clin. Microbiol.34,1996. PubMed PMID:8904432

Detecting selective sweeps in naturally occurring Escherichia coli.
Guttman, DS, Dykhuizen, DE.
Genetics.138,1994. PubMed PMID:7896119

Clonal divergence in Escherichia coli as a result of recombination, not mutation.
Guttman, DS, Dykhuizen, DE.
Science.266,1994. PubMed PMID:7973728

Search PubMed

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