Publications

Guttman Lab on Pubmed
Guttman Lab on Google Scholar

2019
Molecular Evolution of Pseudomonas syringae Type III Secreted Effector Proteins.
Dillon MM, Almeida RND, Laflamme B, Martel A, Weir BS, Desveaux D, Guttman DS.
Front Plant Sci. 2019 Apr 5;10:418. doi: 10.3389/fpls.2019.00418. eCollection 2019.
PMID: 31024592

Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.
Layeghifard M, Li H, Wang PW, Donaldson SL, Coburn B, Clark ST, Caballero JD, Zhang Y, Tullis DE, Yau YCW, Waters V, Hwang DM, Guttman DS.
NPJ Biofilms Microbiomes. 2019 Jan 21;5:4. doi: 10.1038/s41522-018-0077-y. eCollection 2019.
PMID: 30675371

Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.
Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM.
Int J Antimicrob Agents. 2019 May;53(5):620-628. doi: 10.1016/j.ijantimicag.2019.01.009. Epub 2019 Jan 19.
PMID: 30664925

Recombination of ecologically and evolutionarily significant loci maintains genetic cohesion in the Pseudomonas syringae species complex.
Dillon MM, Thakur S, Almeida RND, Wang PW, Weir BS, Guttman DS.
Genome Biol. 2019 Jan 3;20(1):3. doi: 10.1186/s13059-018-1606-y.
PMID: 30606234

Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen.
Lee AH, Bastedo DP, Youn JY, Lo T, Middleton MA, Kireeva I, Lee JY, Sharifpoor S, Baryshnikova A, Zhang J, Wang PW, Peisajovich SG, Constanzo M, Andrews BJ, Boone CM, Desveaux D, Guttman DS.
G3 (Bethesda). 2019 Feb 7;9(2):535-547. doi: 10.1534/g3.118.200877.
PMID: 30573466
2018
A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.
Diaz Caballero, J, Clark, ST, Wang, PW, Donaldson, SL, Coburn, B, Tullis, DE, Yau, YCW, Waters, VJ, Hwang, DM, Guttman, DS.
PLoS Pathog.14,2018. PubMed PMID:30532201

Constructing and Analyzing Microbiome Networks in R.
Layeghifard, M, Hwang, DM, Guttman, DS.
Methods Mol. Biol.1849,2018. PubMed PMID:30298259

Population genomics of bacterial host adaptation.
Sheppard, SK, Guttman, DS, Fitzgerald, JR.
Nat. Rev. Genet.19,2018. PubMed PMID:29973680

Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance.
Clark, ST, Guttman, DS, Hwang, DM.
FEMS Microbiol. Lett.365,2018. PubMed PMID:29401362

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Smakowska-Luzan, E, Mott, GA, Parys, K, Stegmann, M, Howton, TC, Layeghifard, M, Neuhold, J, Lehner, A, Kong, J, Grünwald, K, Weinberger, N, Satbhai, SB, Mayer, D, Busch, W, Madalinski, M, Stolt-Bergner, P, Provart, NJ, Mukhtar, MS, Zipfel, C, Desveaux, D, Guttman, DS, Belkhadir, Y.
Nature.553,2018. PubMed PMID:29320478

A High-Sensitivity, Microtiter-Based Plate Assay for Plant Pattern-Triggered Immunity.
Mott, GA, Desveaux, D, Guttman, DS.
Mol. Plant Microbe Interact.31,2018. PubMed PMID:29199888
2017
Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases.
Seto, D, Koulena, N, Lo, T, Menna, A, Guttman, DS, Desveaux, D.
Nat Plants.3,2017. PubMed PMID:28288096

Disentangling Interactions in the Microbiome: A Network Perspective.
Layeghifard, M, Hwang, DM, Guttman, DS.
Trends Microbiol.25,2017. PubMed PMID:27916383

Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.
Baltrus, DA, McCann, HC, Guttman, DS.
Mol. Plant Pathol.18,2017. PubMed PMID:27798954

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo, T, Koulena, N, Seto, D, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.18,2017. PubMed PMID:27061875
2016
Image-Based Quantification of Plant Immunity and Disease.
Laflamme, B, Middleton, M, Lo, T, Desveaux, D, Guttman, DS.
Mol. Plant Microbe Interact.,2016. PubMed PMID:27996374

Disentangling Interactions in the Microbiome: A Network Perspective.
Layeghifard, M, Hwang, DM, Guttman, DS.
Trends Microbiol.,2016. PubMed PMID:27916383

Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.
Baltrus, DA, McCann, HC, Guttman, DS.
Mol. Plant Pathol.18,2017. PubMed PMID:27798954

Association of host genome with intestinal microbial composition in a large healthy cohort.
Turpin, W, Espin-Garcia, O, Xu, W, Silverberg, MS, Kevans, D, Smith, MI, Guttman, DS, Griffiths, A, Panaccione, R, Otley, A, Xu, L, Shestopaloff, K, Moreno-Hagelsieb, G, GEM Project Research Consortium, Paterson, AD, Croitoru, K.
Nat. Genet.48,2016. PubMed PMID:27694960

Gene Slider: sequence logo interactive data-visualization for education and research.
Waese, J, Pasha, A, Wang, TT, van Weringh, A, Guttman, DS, Provart, NJ.
Bioinformatics.32,2016. PubMed PMID:27522081

A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.
Thakur, S, Guttman, DS.
BMC Bioinformatics.17,2016. PubMed PMID:27363390

Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.
Mott, GA, Thakur, S, Smakowska, E, Wang, PW, Belkhadir, Y, Desveaux, D, Guttman, DS.
Genome Biol.17,2016. PubMed PMID:27160854

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo, T, Koulena, N, Seto, D, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.,2016. PubMed PMID:27061875

Phytopathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae Type and Pathotype Strains.
Thakur, S, Weir, BS, Guttman, DS.
Mol. Plant Microbe Interact.29,2016. PubMed PMID:26883489
2015
Elevated Temperature Differentially Influences Effector-Triggered Immunity Outputs in Arabidopsis.
Menna, A, Nguyen, D, Guttman, DS, Desveaux, D.
Front Plant Sci.6,2015. PubMed PMID:26617631

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
Kim, SH, Clark, ST, Surendra, A, Copeland, JK, Wang, PW, Ammar, R, Collins, C, Tullis, DE, Nislow, C, Hwang, DM, Guttman, DS, Cowen, LE.
PLoS Pathog.11,2015. PubMed PMID:26588216

Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
Diaz Caballero, J, Clark, ST, Coburn, B, Zhang, Y, Wang, PW, Donaldson, SL, Tullis, DE, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
MBio.6,2015. PubMed PMID:26330513

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
Clark, ST, Diaz Caballero, J, Cheang, M, Coburn, B, Wang, PW, Donaldson, SL, Zhang, Y, Liu, M, Keshavjee, S, Yau, YC, Waters, VJ, Elizabeth Tullis, D, Guttman, DS, Hwang, DM.
Sci Rep.5,2015. PubMed PMID:26047320

The human microbiome.
Coburn, B, Guttman, DS.
CMAJ.187,2015. PubMed PMID:25991836

Lung microbiota across age and disease stage in cystic fibrosis.
Coburn, B, Wang, PW, Diaz Caballero, J, Clark, ST, Brahma, V, Donaldson, S, Zhang, Y, Surendra, A, Gong, Y, Elizabeth Tullis, D, Yau, YC, Waters, VJ, Hwang, DM, Guttman, DS.
Sci Rep.5,2015. PubMed PMID:25974282

Seasonal community succession of the phyllosphere microbiome.
Copeland, JK, Yuan, L, Layeghifard, M, Wang, PW, Guttman, DS.
Mol. Plant Microbe Interact.28,2015. PubMed PMID:25679538
2014
Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
Lewis, JD, Wilton, M, Mott, GA, Lu, W, Hassan, JA, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25546415

Proteomics of effector-triggered immunity (ETI) in plants.
Hurley, B, Subramaniam, R, Guttman, DS, Desveaux, D.
Virulence.5,2014. PubMed PMID:25513776

Peptides and small molecules of the plant-pathogen apoplastic arena.
Mott, GA, Middleton, MA, Desveaux, D, Guttman, DS.
Front Plant Sci.5,2014. PubMed PMID:25506352

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.
Hurley, B, Lee, D, Mott, A, Wilton, M, Liu, J, Liu, YC, Angers, S, Coaker, G, Guttman, DS, Desveaux, D.
PLoS ONE.9,2014. PubMed PMID:25503437

Opinion: Conservation and stewardship of the human microbiome.
O'Doherty, KC, Neufeld, JD, Brinkman, FS, Gardner, H, Guttman, DS, Beiko, RG.
Proc. Natl. Acad. Sci. U.S.A.111,2014. PubMed PMID:25294925

Microbial genome-enabled insights into plant-microorganism interactions.
Guttman, DS, McHardy, AC, Schulze-Lefert, P.
Nat. Rev. Genet.15,2014. PubMed PMID:25266034

The rise of the undead: pseudokinases as mediators of effector-triggered immunity.
Lewis, JD, Lo, T, Bastedo, P, Guttman, DS, Desveaux, D.
Plant Signal Behav.9,2014. PubMed PMID:24398910

Next-generation mapping of genetic mutations using bulk population sequencing.
Austin, RS, Chatfield, SP, Desveaux, D, Guttman, DS.
Methods Mol. Biol.1062,2014. PubMed PMID:24057374
2013
The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.
Lewis, JD, Lee, AH, Hassan, JA, Wan, J, Hurley, B, Jhingree, JR, Wang, PW, Lo, T, Youn, JY, Guttman, DS, Desveaux, D.
Proc. Natl. Acad. Sci. U.S.A.110,2013. PubMed PMID:24170858

Phytopathogen type III effectors as probes of biological systems.
Lee, AH, Middleton, MA, Guttman, DS, Desveaux, D.
Microb Biotechnol.6,2013. PubMed PMID:23433088
2012
Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
Schreiber, KJ, Austin, RS, Gong, Y, Zhang, J, Fung, P, Wang, PW, Guttman, DS, Desveaux, D.
BMC Plant Biol.12,2012. PubMed PMID:23176361

Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.
Maughan, H, Wang, PW, Diaz Caballero, J, Fung, P, Gong, Y, Donaldson, SL, Yuan, L, Keshavjee, S, Zhang, Y, Yau, YC, Waters, VJ, Tullis, DE, Hwang, DM, Guttman, DS.
PLoS ONE.7,2012. PubMed PMID:23056217

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Waters, V, Zlosnik, JE, Yau, YC, Speert, DP, Aaron, SD, Guttman, DS.
Eur. J. Clin. Microbiol. Infect. Dis.31,2012. PubMed PMID:22843295

Extensive remodeling of the Pseudomonas syringae pv. avellanae type III secretome associated with two independent host shifts onto hazelnut.
O'Brien, HE, Thakur, S, Gong, Y, Fung, P, Zhang, J, Yuan, L, Wang, PW, Yong, C, Scortichini, M, Guttman, DS.
BMC Microbiol.12,2012. PubMed PMID:22800299

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.
Maughan, H, Cunningham, KS, Wang, PW, Zhang, Y, Cypel, M, Chaparro, C, Tullis, DE, Waddell, TK, Keshavjee, S, Liu, M, Guttman, DS, Hwang, DM.
Pulm Med.2012,2012. PubMed PMID:22448327

Identification of innate immunity elicitors using molecular signatures of natural selection.
McCann, HC, Nahal, H, Thakur, S, Guttman, DS.
Proc. Natl. Acad. Sci. U.S.A.109,2012. PubMed PMID:22323605

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.
Lee, AH, Hurley, B, Felsensteiner, C, Yea, C, Ckurshumova, W, Bartetzko, V, Wang, PW, Quach, V, Lewis, JD, Liu, YC, Börnke, F, Angers, S, Wilde, A, Guttman, DS, Desveaux, D.
PLoS Pathog.8,2012. PubMed PMID:22319451

Quantitative Interactor Screening with next-generation Sequencing (QIS-Seq) identifies Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2.
Lewis, JD, Wan, J, Ford, R, Gong, Y, Fung, P, Nahal, H, Wang, PW, Desveaux, D, Guttman, DS.
BMC Genomics.13,2012. PubMed PMID:22230763

E622, a miniature, virulence-associated mobile element.
Stavrinides, J, Kirzinger, MW, Beasley, FC, Guttman, DS.
J. Bacteriol.194,2012. PubMed PMID:22081398
2011
Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.
O'Brien, HE, Gong, Y, Fung, P, Wang, PW, Guttman, DS.
PLoS ONE.6,2011. PubMed PMID:22073286

The YopJ superfamily in plant-associated bacteria.
Lewis, JD, Lee, A, Ma, W, Zhou, H, Guttman, DS, Desveaux, D.
Mol. Plant Pathol.12,2011. PubMed PMID:21726386

Evolution of plant pathogenesis in Pseudomonas syringae: a genomics perspective.
O'Brien, HE, Thakur, S, Guttman, DS.
Annu Rev Phytopathol.49,2011. PubMed PMID:21568703

Next-generation mapping of Arabidopsis genes.
Austin, RS, Vidaurre, D, Stamatiou, G, Breit, R, Provart, NJ, Bonetta, D, Zhang, J, Fung, P, Gong, Y, Wang, PW, McCourt, P, Guttman, DS.
Plant J.67,2011. PubMed PMID:21518053

Next-generation genomics of Pseudomonas syringae.
O'Brien, HE, Desveaux, D, Guttman, DS.
Curr. Opin. Microbiol.14,2011. PubMed PMID:21233007
2010
Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein.
Lewis, JD, Wu, R, Guttman, DS, Desveaux, D.
PLoS Genet.6,2010. PubMed PMID:20368970
2009
Bacterial evolution: dynamic genomes and the power of transformation.
Guttman, DS.
Curr. Biol.19,2009. PubMed PMID:19788881

The targeting of plant cellular systems by injected type III effector proteins.
Lewis, JD, Guttman, DS, Desveaux, D.
Semin. Cell Dev. Biol.20,2009. PubMed PMID:19540926

Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems.
Zhou, H, Morgan, RL, Guttman, DS, Ma, W.
Mol. Plant Microbe Interact.22,2009. PubMed PMID:19132870
2008
Evolution of prokaryotic and eukaryotic virulence effectors.
Ma, W, Guttman, DS.
Curr. Opin. Plant Biol.11,2008. PubMed PMID:18585954

New and sensitive assay for determining Pseudomonas aeruginosa metallo-beta-lactamase resistance to imipenem.
Tan, J, Pitout, JD, Guttman, DS.
J. Clin. Microbiol.46,2008. PubMed PMID:18337388

The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thaliana.
Lewis, JD, Abada, W, Ma, W, Guttman, DS, Desveaux, D.
J. Bacteriol.190,2008. PubMed PMID:18263728

Evolution of the type III secretion system and its effectors in plant-microbe interactions.
McCann, HC, Guttman, DS.
New Phytol.177,2008. PubMed PMID:18078471

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865
2007
Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides, J, McCann, HC, Guttman, DS.
Cell. Microbiol.10,2008. PubMed PMID:18034865

Convergent evolution of phytopathogenic pseudomonads onto hazelnut.
Wang, PW, Morgan, RL, Scortichini, M, Guttman, DS.
Microbiology (Reading, Engl.).153,2007. PubMed PMID:17600051
2006
Type III effector diversification via both pathoadaptation and horizontal transfer in response to a coevolutionary arms race.
Ma, W, Dong, FF, Stavrinides, J, Guttman, DS.
PLoS Genet.2,2006. PubMed PMID:17194219

Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Vencato, M, Tian, F, Alfano, JR, Buell, CR, Cartinhour, S, DeClerck, GA, Guttman, DS, Stavrinides, J, Joardar, V, Lindeberg, M, Bronstein, PA, Mansfield, JW, Myers, CR, Collmer, A, Schneider, DJ.
Mol. Plant Microbe Interact.19,2006. PubMed PMID:17073302

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens.
Stavrinides, J, Ma, W, Guttman, DS.
PLoS Pathog.2,2006. PubMed PMID:17040127

Comparative genomics of host-specific virulence in Pseudomonas syringae.
Sarkar, SF, Gordon, JS, Martin, GB, Guttman, DS.
Genetics.174,2006. PubMed PMID:16951068

Diversifying selection drives the evolution of the type III secretion system pilus of Pseudomonas syringae.
Guttman, DS, Gropp, SJ, Morgan, RL, Wang, PW.
Mol. Biol. Evol.23,2006. PubMed PMID:16950758
2005
Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae.
Hwang, MS, Morgan, RL, Sarkar, SF, Wang, PW, Guttman, DS.
Appl. Environ. Microbiol.71,2005. PubMed PMID:16151103

Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae.
Lindeberg, M, Stavrinides, J, Chang, JH, Alfano, JR, Collmer, A, Dangl, JL, Greenberg, JT, Mansfield, JW, Guttman, DS.
Mol. Plant Microbe Interact.18,2005. PubMed PMID:15828679
2004
Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringae.
Rohmer, L, Guttman, DS, Dangl, JL.
Genetics.167,2004. PubMed PMID:15280247

Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.
Stavrinides, J, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:15262947

Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.
Sarkar, SF, Guttman, DS.
Appl. Environ. Microbiol.70,2004. PubMed PMID:15066790

Plants as models for the study of human pathogenesis.
Guttman, DS.
Biotechnol. Adv.22,2004. PubMed PMID:15063457

The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.
Gropp, SJ, Guttman, DS.
Mol. Plant Pathol.5,2004. PubMed PMID:20565590

Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.
Wang, PW, Chu, L, Guttman, DS.
J. Bacteriol.186,2004. PubMed PMID:14702309

Mosaic evolution of the severe acute respiratory syndrome coronavirus.
Stavrinides, J, Guttman, DS.
J. Virol.78,2004. PubMed PMID:14671089
2002
A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.
Guttman, DS, Vinatzer, BA, Sarkar, SF, Ranall, MV, Kettler, G, Greenberg, JT.
Science.295,2002. PubMed PMID:11872842
2001
Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system.
Guttman, DS, Greenberg, JT.
Mol. Plant Microbe Interact.14,2001. PubMed PMID:11204777
Earlier Publications
An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.
Guttman, DS, Charlesworth, D.
Nature.393,1998. PubMed PMID:9607762

Recombination and clonality in natural populations of Escherichia coli.
Guttman, DS.
Trends Ecol. Evol. (Amst.).12,1997. PubMed PMID:21237956

Seeing selection in S allele sequences.
Charlesworth, D, Guttman, DS.
Curr. Biol.7,1997. PubMed PMID:9072167

Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Guttman, DS, Wang, PW, Wang, IN, Bosler, EM, Luft, BJ, Dykhuizen, DE.
J. Clin. Microbiol.34,1996. PubMed PMID:8904432

Detecting selective sweeps in naturally occurring Escherichia coli.
Guttman, DS, Dykhuizen, DE.
Genetics.138,1994. PubMed PMID:7896119

Clonal divergence in Escherichia coli as a result of recombination, not mutation.
Guttman, DS, Dykhuizen, DE.
Science.266,1994. PubMed PMID:7973728

2019
Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models.
Robertson SJ, Lemire P, Maughan H, Goethel A, Turpin W, Bedrani L, Guttman DS, Croitoru K, Girardin SE, Philpott DJ.
Cell Rep. 2019 May 7;27(6):1910-1919.e2. doi: 10.1016/j.celrep.2019.04.023.
PMID: 31067473

Molecular Evolution of Pseudomonas syringae Type III Secreted Effector Proteins.
Dillon MM, Almeida RND, Laflamme B, Martel A, Weir BS, Desveaux D, Guttman DS.
Front Plant Sci. 2019 Apr 5;10:418. doi: 10.3389/fpls.2019.00418. eCollection 2019.
PMID: 31024592

Mycobiome Sequencing and Analysis Applied to Fungal Community Profiling of the Lower Respiratory Tract During Fungal Pathogenesis.
McTaggart LR, Copeland JK, Surendra A, Wang PW, Husain S, Coburn B, Guttman DS, Kus JV.
Front Microbiol. 2019 Mar 15;10:512. doi: 10.3389/fmicb.2019.00512. eCollection 2019.
PMID: 30930884

Map of physical interactions between extracellular domains of Arabidopsis leucine-rich repeat receptor kinases.
Mott GA, Smakowska-Luzan E, Pasha A, Parys K, Howton TC, Neuhold J, Lehner A, Grünwald K, Stolt-Bergner P, Provart NJ, Mukhtar MS, Desveaux D, Guttman DS, Belkhadir Y.
Sci Data. 2019 Feb 26;6:190025. doi: 10.1038/sdata.2019.25.
PMID: 30806640

Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.
Layeghifard M, Li H, Wang PW, Donaldson SL, Coburn B, Clark ST, Caballero JD, Zhang Y, Tullis DE, Yau YCW, Waters V, Hwang DM, Guttman DS.
NPJ Biofilms Microbiomes. 2019 Jan 21;5:4. doi: 10.1038/s41522-018-0077-y. eCollection 2019.
PMID: 30675371

Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.
Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM.
Int J Antimicrob Agents. 2019 May;53(5):620-628. doi: 10.1016/j.ijantimicag.2019.01.009. Epub 2019 Jan 19.
PMID: 30664925

Recombination of ecologically and evolutionarily significant loci maintains genetic cohesion in the Pseudomonas syringae species complex.
Dillon MM, Thakur S, Almeida RND, Wang PW, Weir BS, Guttman DS.
Genome Biol. 2019 Jan 3;20(1):3. doi: 10.1186/s13059-018-1606-y.
PMID: 30606234

Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen.
Lee AH, Bastedo DP, Youn JY, Lo T, Middleton MA, Kireeva I, Lee JY, Sharifpoor S, Baryshnikova A, Zhang J, Wang PW, Peisajovich SG, Constanzo M, Andrews BJ, Boone CM, Desveaux D, Guttman DS.
G3 (Bethesda). 2019 Feb 7;9(2):535-547. doi: 10.1534/g3.118.200877.
PMID: 30573466
2018
Design and application of a novel two-amplicon approach for defining eukaryotic microbiota.
Popovic A, Bourdon C, Wang PW, Guttman DS, Voskuijl W, Grigg ME, Bandsma RHJ, Parkinson J.
Microbiome. 2018 Dec 20;6(1):228. doi: 10.1186/s40168-018-0612-3.
PMID: 30572961

A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.
Diaz Caballero J, Clark ST, Wang PW, Donaldson SL, Coburn B, Tullis DE, Yau YCW, Waters VJ, Hwang DM, Guttman DS.
PLoS Pathog. 2018 Dec 7;14(12):e1007453. doi: 10.1371/journal.ppat.1007453. eCollection 2018 Dec.
PMID: 30532201

Constructing and Analyzing Microbiome Networks in R.
Layeghifard M, Hwang DM, Guttman DS.
Methods Mol Biol. 2018;1849:243-266. doi: 10.1007/978-1-4939-8728-3_16.
PMID: 30298259

Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children.
Tun MH, Tun HM, Mahoney JJ, Konya TB, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Brook JR, Lou W, Takaro TK, Scott JA, Kozyrskyj AL; CHILD Study Investigators.
CMAJ. 2018 Sep 17;190(37):E1097-E1107. doi: 10.1503/cmaj.170809. Erratum in: CMAJ. 2018 Nov 12;190(45):E1341.
PMID: 30224442

Chloroplast sequence variation and the efficacy of peptide nucleic acids for blocking host amplification in plant microbiome studies.
Fitzpatrick CR, Lu-Irving P, Copeland J, Guttman DS, Wang PW, Baltrus DA, Dlugosch KM, Johnson MTJ.
Microbiome. 2018 Aug 18;6(1):144. doi: 10.1186/s40168-018-0534-0.
PMID: 30121081

Population genomics of bacterial host adaptation.
Sheppard SK, Guttman DS, Fitzgerald JR.
Nat Rev Genet. 2018 Sep;19(9):549-565. doi: 10.1038/s41576-018-0032-z. Review.
PMID: 29973680

Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population.
Middleton MA, Layeghifard M, Klingel M, Stanojevic S, Yau YCW, Zlosnik JEA, Coriati A, Ratjen FA, Tullis ED, Stephenson A, Wilcox P, Freitag A, Chilvers M, McKinney M, Lavoie A, Wang PW, Guttman DS, Waters VJ.
Ann Am Thorac Soc. 2018 Jul;15(7):827-836. doi: 10.1513/AnnalsATS.201801-007OC.
PMID: 29911888

Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life.
Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, Field CJ, Lefebvre D, Sears MR, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Scott JA, Kozyrskyj AL; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators.
JAMA Pediatr. 2018 Jul 2;172(7):e181161. doi: 10.1001/jamapediatrics.2018.1161. Epub 2018 Jul 2.
PMID: 29868719

FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.
Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MI, Guttman DS, Griffiths A, Moayyedi P, Panaccione R, Huynh H, Steinhart H, Aumais G, Shestopaloff K, Dieleman LA, Turner D, Paterson AD, Croitoru K.
Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
PMID: 29533703
2017
Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.
Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators.
JAMA Pediatr. 2018 Apr 1;172(4):368-377. doi: 10.1001/jamapediatrics.2017.5535.
PMID: 29459942

Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance.
Clark ST, Guttman DS, Hwang DM.
FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny026.
PMID: 29401362

Assembly and ecological function of the root microbiome across angiosperm plant species.
Fitzpatrick CR, Copeland J, Wang PW, Guttman DS, Kotanen PM, Johnson MTJ.
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1157-E1165. doi: 10.1073/pnas.1717617115. Epub 2018 Jan 22.
PMID: 29358405

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y.
Nature. 2018 Jan 18;553(7688):342-346. doi: 10.1038/nature25184. Epub 2018 Jan 10. Erratum in: Nature. 2018 Sep;561(7722):E8.
PMID: 29320478

A High-Sensitivity, Microtiter-Based Plate Assay for Plant Pattern-Triggered Immunity.
Mott GA, Desveaux D, Guttman DS.
Mol Plant Microbe Interact. 2018 May;31(5):499-504. doi: 10.1094/MPMI-11-17-0279-TA. Epub 2018 Feb 28.
PMID: 29199888

Identification and analysis of seven effector protein families with different adaptive and evolutionary histories in plant-associated members of the Xanthomonadaceae.
Assis RAB, Polloni LC, Patané JSL, Thakur S, Felestrino ÉB, Diaz-Caballero J, Digiampietri LA, Goulart LR, Almeida NF, Nascimento R, Dandekar AM, Zaini PA, Setubal JC, Guttman DS, Moreira LM.
Sci Rep. 2017 Nov 23;7(1):16133. doi: 10.1038/s41598-017-16325-1.
PMID: 29170530

Sex-specific impact of asthma during pregnancy on infant gut microbiota.
Koleva PT, Tun HM, Konya T, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators.
Eur Respir J. 2017 Nov 22;50(5). pii: 1700280. doi: 10.1183/13993003.00280-2017. Print 2017 Nov.
PMID: 29167295

Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance.
Beaudoin T, Yau YCW, Stapleton PJ, Gong Y, Wang PW, Guttman DS, Waters V.
NPJ Biofilms Microbiomes. 2017 Oct 19;3:25. doi: 10.1038/s41522-017-0035-0. eCollection 2017.
PMID: 29062489

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Yasmin F, Tun HM, Konya TB, Guttman DS, Chari RS, Field CJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR; CHILD Study Investigators, Scott JA, Dinu I, Kozyrskyj AL.
Front Pediatr. 2017 Sep 26;5:200. doi: 10.3389/fped.2017.00200. eCollection 2017.
PMID: 29018787

Impact of Immunosuppression on the Metagenomic Composition of the Intestinal Microbiome: a Systems Biology Approach to Post-Transplant Diabetes.
Bhat M, Pasini E, Copeland J, Angeli M, Husain S, Kumar D, Renner E, Teterina A, Allard J, Guttman DS, Humar A.
Sci Rep. 2017 Aug 31;7(1):10277. doi: 10.1038/s41598-017-10471-2.
PMID: 28860611

A Practical Guide to Quantitative Interactor Screening with Next-Generation Sequencing (QIS-Seq).
Gong Y, Desveaux D, Guttman DS, Lewis JD.
Methods Mol Biol. 2017;1613:1-20. doi: 10.1007/978-1-4939-7027-8_1.
PMID: 28849555

Draft Genome Sequences of 10 Environmental Pseudomonas aeruginosa Strains Isolated from Soils, Sediments, and Waters.
Shrestha SD, Guttman DS, Perron GG.
Genome Announc. 2017 Aug 24;5(34). pii: e00804-17. doi: 10.1128/genomeA.00804-17.
PMID: 28839021

Topo-phylogeny: Visualizing evolutionary relationships on a topographic landscape.
Waese J, Provart NJ, Guttman DS.
PLoS One. 2017 May 1;12(5):e0175895. doi: 10.1371/journal.pone.0175895. eCollection 2017.
PMID: 28459802

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.
Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators.
Microbiome. 2017 Apr 6;5(1):40. doi: 10.1186/s40168-017-0254-x.
PMID: 28381231

Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases.
Seto D, Koulena N, Lo T, Menna A, Guttman DS, Desveaux D.
Nat Plants. 2017 Mar 13;3:17027. doi: 10.1038/nplants.2017.27.
PMID: 28288096

Navigating social and ethical challenges of biobanking for human microbiome research.
Chuong KH, Hwang DM, Tullis DE, Waters VJ, Yau YC, Guttman DS, O'Doherty KC.
BMC Med Ethics. 2017 Jan 11;18(1):1. doi: 10.1186/s12910-016-0160-y.
PMID: 28077127
2016
Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial.
Hota SS, Sales V, Tomlinson G, Salpeter MJ, McGeer A, Coburn B, Guttman DS, Low DE, Poutanen SM.
Clin Infect Dis. 2017 Feb 1;64(3):265-271. doi: 10.1093/cid/ciw731. Epub 2016 Nov 9.
PMID: 28011612

Image-Based Quantification of Plant Immunity and Disease.
Laflamme B, Middleton M, Lo T, Desveaux D, Guttman DS.
Mol Plant Microbe Interact. 2016 Dec;29(12):919-924. doi: 10.1094/MPMI-07-16-0129-TA. Epub 2016 Dec 20.
PMID: 27996374

Disentangling Interactions in the Microbiome: A Network Perspective.
Layeghifard M, Hwang DM, Guttman DS.
Trends Microbiol. 2017 Mar;25(3):217-228. doi: 10.1016/j.tim.2016.11.008. Epub 2016 Dec 2. Review.
PMID: 27916383

NKT Cell-Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis.
Selvanantham T, Lin Q, Guo CX, Surendra A, Fieve S, Escalante NK, Guttman DS, Streutker CJ, Robertson SJ, Philpott DJ, Mallevaey T.
J Immunol. 2016 Dec 1;197(11):4464-4472. Epub 2016 Oct 31.
PMID: 27799307

Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.
Baltrus DA, McCann HC, Guttman DS.
Mol Plant Pathol. 2017 Jan;18(1):152-168. doi: 10.1111/mpp.12506. Epub 2016 Nov 25. Review.
PMID: 27798954

Association of host genome with intestinal microbial composition in a large healthy cohort.
Turpin W, Espin-Garcia O, Xu W, Silverberg MS, Kevans D, Smith MI, Guttman DS, Griffiths A, Panaccione R, Otley A, Xu L, Shestopaloff K, Moreno-Hagelsieb G; GEM Project Research Consortium, Paterson AD, Croitoru K.
Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
PMID: 27694960

Gene Slider: sequence logo interactive data-visualization for education and research.
Waese J, Pasha A, Wang TT, van Weringh A, Guttman DS, Provart NJ.
Bioinformatics. 2016 Dec 1;32(23):3670-3672. Epub 2016 Aug 13.
PMID: 27522081

A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.
Thakur S, Guttman DS.
BMC Bioinformatics. 2016 Jun 30;17(1):260. doi: 10.1186/s12859-016-1142-2.
PMID: 27363390

Prophages mediate defense against phage infection through diverse mechanisms.
Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL.
ISME J. 2016 Dec;10(12):2854-2866. doi: 10.1038/ismej.2016.79. Epub 2016 Jun 3.
PMID: 27258950

High fecal IgA is associated with reduced Clostridium difficile colonization in infants.
Bridgman SL, Konya T, Azad MB, Guttman DS, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P; CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL.
Microbes Infect. 2016 Sep;18(9):543-9. doi: 10.1016/j.micinf.2016.05.001. Epub 2016 May 24.
PMID: 27235197

Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.
Mott GA, Thakur S, Smakowska E, Wang PW, Belkhadir Y, Desveaux D, Guttman DS.
Genome Biol. 2016 May 9;17:98. doi: 10.1186/s13059-016-0955-7.
PMID: 27160854

The HopF family of Pseudomonas syringae type III secreted effectors.
Lo T, Koulena N, Seto D, Guttman DS, Desveaux D.
Mol Plant Pathol. 2017 Apr;18(3):457-468. doi: 10.1111/mpp.12412. Epub 2016 Jun 9. Review.
PMID: 27061875

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.
Ryczko MC, Pawling J, Chen R, Abdel Rahman AM, Yau K, Copeland JK, Zhang C, Surendra A, Guttman DS, Figeys D, Dennis JW.
Sci Rep. 2016 Mar 14;6:23043. doi: 10.1038/srep23043.
PMID: 26972830

Phytopathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae Type and Pathotype Strains.
Thakur S, Weir BS, Guttman DS.
Mol Plant Microbe Interact. 2016 Apr;29(4):243-6. doi: 10.1094/MPMI-01-16-0013-TA. Epub 2016 Mar 17.
PMID: 26883489
2015
Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola.
Sistrom M, Park D, O'Brien HE, Wang Z, Guttman DS, Townsend JP, Turner PE.
PLoS One. 2015 Dec 15;10(12):e0144514. doi: 10.1371/journal.pone.0144514. eCollection 2015.
PMID: 26670219

Elevated Temperature Differentially Influences Effector-Triggered Immunity Outputs in Arabidopsis.
Menna A, Nguyen D, Guttman DS, Desveaux D.
Front Plant Sci. 2015 Nov 9;6:995. doi: 10.3389/fpls.2015.00995. eCollection 2015.
PMID: 26617631

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.
Kim SH, Clark ST, Surendra A, Copeland JK, Wang PW, Ammar R, Collins C, Tullis DE, Nislow C, Hwang DM, Guttman DS, Cowen LE.
PLoS Pathog. 2015 Nov 20;11(11):e1005308. doi: 10.1371/journal.ppat.1005308. eCollection 2015 Nov.
PMID: 26588216

Chronic infection phenotypes of Pseudomonas aeruginosa are associated with failure of eradication in children with cystic fibrosis.
Vidya P, Smith L, Beaudoin T, Yau YC, Clark S, Coburn B, Guttman DS, Hwang DM, Waters V.
Eur J Clin Microbiol Infect Dis. 2016 Jan;35(1):67-74.
PMID: 26492874

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators.
BJOG. 2016 May;123(6):983-93. doi: 10.1111/1471-0528.13601. Epub 2015 Sep 28.
PMID: 26412384

Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.
Diaz Caballero J, Clark ST, Coburn B, Zhang Y, Wang PW, Donaldson SL, Tullis DE, Yau YC, Waters VJ, Hwang DM, Guttman DS.
MBio. 2015 Sep 1;6(5):e00981-15. doi: 10.1128/mBio.00981-15.
PMID: 26330513

Comparative genomic analysis of multiple strains of two unusual plant pathogens: Pseudomonas corrugata and Pseudomonas mediterranea.
Trantas EA, Licciardello G, Almeida NF, Witek K, Strano CP, Duxbury Z, Ververidis F, Goumas DE, Jones JD, Guttman DS, Catara V, Sarris PF.
Front Microbiol. 2015 Aug 7;6:811. doi: 10.3389/fmicb.2015.00811. eCollection 2015.
PMID: 26300874

Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.
Clark ST, Diaz Caballero J, Cheang M, Coburn B, Wang PW, Donaldson SL, Zhang Y, Liu M, Keshavjee S, Yau YC, Waters VJ, Elizabeth Tullis D, Guttman DS, Hwang DM.
Sci Rep. 2015 Jun 5;5:10932. doi: 10.1038/srep10932.
PMID: 26047320

The human microbiome.
Coburn B, Guttman DS.
CMAJ. 2015 Aug 11;187(11):825. doi: 10.1503/cmaj.141072. Epub 2015 May 19. Review. No abstract available.
PMID: 25991836

Lung microbiota across age and disease stage in cystic fibrosis.
Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S, Zhang Y, Surendra A, Gong Y, Elizabeth Tullis D, Yau YC, Waters VJ, Hwang DM, Guttman DS.
Sci Rep. 2015 May 14;5:10241. doi: 10.1038/srep10241.
PMID: 25974282

Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.
Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.
Cell Metab. 2015 Apr 7;21(4):527-42. doi: 10.1016/j.cmet.2015.03.001.
PMID: 25863246

Seasonal community succession of the phyllosphere microbiome.
Copeland JK, Yuan L, Layeghifard M, Wang PW, Guttman DS.
Mol Plant Microbe Interact. 2015 Mar;28(3):274-85. doi: 10.1094/MPMI-10-14-0331-FI.
PMID: 25679538

Infant gut microbiota and food sensitization: associations in the first year of life.
Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators.
Clin Exp Allergy. 2015 Mar;45(3):632-43. doi: 10.1111/cea.12487.
PMID: 25599982
2014
Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
Lewis JD, Wilton M, Mott GA, Lu W, Hassan JA, Guttman DS, Desveaux D.
PLoS One. 2014 Dec 29;9(12):e116152. doi: 10.1371/journal.pone.0116152. eCollection 2014.
PMID: 25546415

Proteomics of effector-triggered immunity (ETI) in plants.
Hurley B, Subramaniam R, Guttman DS, Desveaux D.
Virulence. 2014;5(7):752-60. doi: 10.4161/viru.36329. Review.
PMID: 25513776

Peptides and small molecules of the plant-pathogen apoplastic arena.
Mott GA, Middleton MA, Desveaux D, Guttman DS.
Front Plant Sci. 2014 Nov 28;5:677. doi: 10.3389/fpls.2014.00677. eCollection 2014. Review.
PMID: 25506352

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.
Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D.
PLoS One. 2014 Dec 11;9(12):e114921. doi: 10.1371/journal.pone.0114921. eCollection 2014.
PMID: 25503437

Opinion: Conservation and stewardship of the human microbiome.
O'Doherty KC, Neufeld JD, Brinkman FS, Gardner H, Guttman DS, Beiko RG.
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14312-3. doi: 10.1073/pnas.1413200111. No abstract available.
PMID: 25294925

Microbial genome-enabled insights into plant-microorganism interactions.
Guttman DS, McHardy AC, Schulze-Lefert P.
Nat Rev Genet. 2014 Dec;15(12):797-813. doi: 10.1038/nrg3748. Epub 2014 Sep 30. Review.
PMID: 25266034

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.
Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Surendra A, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TMS, Edelmann W, Guttman DS, Philpott DJ, Martin A.
Cell. 2014 Jul 17;158(2):288-299. doi: 10.1016/j.cell.2014.04.051. Erratum in: Cell. 2014 Oct 9;159(2):456.
PMID: 25036629

Associations between bacterial communities of house dust and infant gut.
Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA; CHILD Study Investigators.
Environ Res. 2014 May;131:25-30. doi: 10.1016/j.envres.2014.02.005. Epub 2014 Mar 15.
PMID: 24637181

HopZ4 from Pseudomonas syringae, a member of the HopZ type III effector family from the YopJ superfamily, inhibits the proteasome in plants.
Üstün S, König P, Guttman DS, Börnke F.
Mol Plant Microbe Interact. 2014 Jul;27(7):611-23. doi: 10.1094/MPMI-12-13-0363-R.
PMID: 24625030

The rise of the undead: pseudokinases as mediators of effector-triggered immunity.
Lewis JD, Lo T, Bastedo P, Guttman DS, Desveaux D.
Plant Signal Behav. 2014;9(1):e27563. Epub 2014 Jan 7.
PMID: 24398910
2013
The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.
Lewis JD, Lee AH, Hassan JA, Wan J, Hurley B, Jhingree JR, Wang PW, Lo T, Youn JY, Guttman DS, Desveaux D.
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18722-7. doi: 10.1073/pnas.1315520110. Epub 2013 Oct 29.
PMID: 24170858

Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis.
Tyler AD, Knox N, Kabakchiev B, Milgrom R, Kirsch R, Cohen Z, McLeod RS, Guttman DS, Krause DO, Silverberg MS.
PLoS One. 2013 Sep 24;8(9):e66934. doi: 10.1371/journal.pone.0066934. eCollection 2013.
PMID: 24086242

Next-generation mapping of genetic mutations using bulk population sequencing.
Austin RS, Chatfield SP, Desveaux D, Guttman DS.
Methods Mol Biol. 2014;1062:301-15. doi: 10.1007/978-1-62703-580-4_17.
PMID: 24057374

Genomic analysis of the Kiwifruit pathogen Pseudomonas syringae pv. actinidiae provides insight into the origins of an emergent plant disease.
McCann HC, Rikkerink EH, Bertels F, Fiers M, Lu A, Rees-George J, Andersen MT, Gleave AP, Haubold B, Wohlers MW, Guttman DS, Wang PW, Straub C, Vanneste JL, Rainey PB, Templeton MD.
PLoS Pathog. 2013;9(7):e1003503. doi: 10.1371/journal.ppat.1003503. Epub 2013 Jul 25. Erratum in: PLoS Pathog. 2013;9(9). doi:10.1371/annotation/af157ddc-200a-4105-b243-3f01251cc677. Vanneste, Joel [corrected to Vanneste, Joel L].
PMID: 23935484

Neutral genomic microevolution of a recently emerged pathogen, Salmonella enterica serovar Agona.
Zhou Z, McCann A, Litrup E, Murphy R, Cormican M, Fanning S, Brown D, Guttman DS, Brisse S, Achtman M.
PLoS Genet. 2013 Apr;9(4):e1003471. doi: 10.1371/journal.pgen.1003471. Epub 2013 Apr 18.
PMID: 23637636

Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity.
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Sears MR, Becker AB, Scott JA, Kozyrskyj AL.
Allergy Asthma Clin Immunol. 2013 Apr 22;9(1):15. doi: 10.1186/1710-1492-9-15. eCollection 2013.
PMID: 23607879

Phytopathogen type III effectors as probes of biological systems.
Lee AH, Middleton MA, Guttman DS, Desveaux D.
Microb Biotechnol. 2013 May;6(3):230-40. doi: 10.1111/1751-7915.12042. Epub 2013 Feb 25. Review.
PMID: 23433088

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators.
CMAJ. 2013 Mar 19;185(5):385-94. doi: 10.1503/cmaj.121189. Epub 2013 Feb 11.
PMID: 23401405
2012
Gut microbiota diversity and atopic disease: does breast-feeding play a role?
Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL; Canadian Healthy Infant Longitudinal Development Study Investigators.
J Allergy Clin Immunol. 2013 Jan;131(1):247-8. doi: 10.1016/j.jaci.2012.10.044. Epub 2012 Nov 27. No abstract available.
PMID: 23199602

Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
Schreiber KJ, Austin RS, Gong Y, Zhang J, Fung P, Wang PW, Guttman DS, Desveaux D.
BMC Plant Biol. 2012 Nov 24;12:226. doi: 10.1186/1471-2229-12-226.
PMID: 23176361

Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.
Maughan H, Wang PW, Diaz Caballero J, Fung P, Gong Y, Donaldson SL, Yuan L, Keshavjee S, Zhang Y, Yau YC, Waters VJ, Tullis DE, Hwang DM, Guttman DS.
PLoS One. 2012;7(10):e45791. doi: 10.1371/journal.pone.0045791. Epub 2012 Oct 2.
PMID: 23056217

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Waters V, Zlosnik JE, Yau YC, Speert DP, Aaron SD, Guttman DS.
Eur J Clin Microbiol Infect Dis. 2012 Dec;31(12):3341-50. doi: 10.1007/s10096-012-1701-z. Epub 2012 Jul 29.
PMID: 22843295

Extensive remodeling of the Pseudomonas syringae pv. avellanae type III secretome associated with two independent host shifts onto hazelnut.
O'Brien HE, Thakur S, Gong Y, Fung P, Zhang J, Yuan L, Wang PW, Yong C, Scortichini M, Guttman DS.
BMC Microbiol. 2012 Jul 16;12:141. doi: 10.1186/1471-2180-12-141.
PMID: 22800299

Pseudomonas syringae pv. actinidiae (PSA) isolates from recent bacterial canker of kiwifruit outbreaks belong to the same genetic lineage.
Mazzaglia A, Studholme DJ, Taratufolo MC, Cai R, Almeida NF, Goodman T, Guttman DS, Vinatzer BA, Balestra GM.
PLoS One. 2012;7(5):e36518. doi: 10.1371/journal.pone.0036518. Epub 2012 May 9.
PMID: 22590555

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.
Maughan H, Cunningham KS, Wang PW, Zhang Y, Cypel M, Chaparro C, Tullis DE, Waddell TK, Keshavjee S, Liu M, Guttman DS, Hwang DM.
Pulm Med. 2012;2012:746358. doi: 10.1155/2012/746358. Epub 2012 Feb 8.
PMID: 22448327

Identification of innate immunity elicitors using molecular signatures of natural selection.
McCann HC, Nahal H, Thakur S, Guttman DS.
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4215-20. doi: 10.1073/pnas.1113893109. Epub 2012 Feb 9.
PMID: 22323605

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.
Lee AH, Hurley B, Felsensteiner C, Yea C, Ckurshumova W, Bartetzko V, Wang PW, Quach V, Lewis JD, Liu YC, Börnke F, Angers S, Wilde A, Guttman DS, Desveaux D.
PLoS Pathog. 2012 Feb;8(2):e1002523. doi: 10.1371/journal.ppat.1002523. Epub 2012 Feb 2.
PMID: 22319451
2011
Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.
Lee SJ, Lee J, Li KK, Holland D, Maughan H, Guttman DS, Yusta B, Drucker DJ.
Endocrinology. 2012 Mar;153(3):1141-51. doi: 10.1210/en.2011-1954. Epub 2012 Jan 17.
PMID: 22253424

Quantitative Interactor Screening with next-generation Sequencing (QIS-Seq) identifies Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2.
Lewis JD, Wan J, Ford R, Gong Y, Fung P, Nahal H, Wang PW, Desveaux D, Guttman DS.
BMC Genomics. 2012 Jan 9;13:8. doi: 10.1186/1471-2164-13-8.
PMID: 22230763

E622, a miniature, virulence-associated mobile element.
Stavrinides J, Kirzinger MW, Beasley FC, Guttman DS.
J Bacteriol. 2012 Jan;194(2):509-17. doi: 10.1128/JB.06211-11. Epub 2011 Nov 11.
PMID: 22081398

Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.
O'Brien HE, Gong Y, Fung P, Wang PW, Guttman DS.
PLoS One. 2011;6(11):e27199. doi: 10.1371/journal.pone.0027199. Epub 2011 Nov 2.
PMID: 22073286

HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens.
Sohn KH, Saucet SB, Clarke CR, Vinatzer BA, O'Brien HE, Guttman DS, Jones JD.
New Phytol. 2012 Jan;193(1):58-66. doi: 10.1111/j.1469-8137.2011.03950.x. Epub 2011 Nov 4.
PMID: 22053875

Tri6 is a global transcription regulator in the phytopathogen Fusarium graminearum.
Nasmith CG, Walkowiak S, Wang L, Leung WW, Gong Y, Johnston A, Harris LJ, Guttman DS, Subramaniam R.
PLoS Pathog. 2011 Sep;7(9):e1002266. doi: 10.1371/journal.ppat.1002266. Epub 2011 Sep 29.
PMID: 21980289

The YopJ superfamily in plant-associated bacteria.
Lewis JD, Lee A, Ma W, Zhou H, Guttman DS, Desveaux D.
Mol Plant Pathol. 2011 Dec;12(9):928-37. doi: 10.1111/j.1364-3703.2011.00719.x. Epub 2011 May 12. Review.
PMID: 21726386

Evolution of plant pathogenesis in Pseudomonas syringae: a genomics perspective.
O'Brien HE, Thakur S, Guttman DS.
Annu Rev Phytopathol. 2011;49:269-89. doi: 10.1146/annurev-phyto-072910-095242. Review.
PMID: 21568703

Next-generation mapping of Arabidopsis genes.
Austin RS, Vidaurre D, Stamatiou G, Breit R, Provart NJ, Bonetta D, Zhang J, Fung P, Gong Y, Wang PW, McCourt P, Guttman DS.
Plant J. 2011 Aug;67(4):715-25. doi: 10.1111/j.1365-313X.2011.04619.x. Epub 2011 Jul 18.
PMID: 21518053

Transcriptomic responses of the softwood-degrading white-rot fungus Phanerochaete carnosa during growth on coniferous and deciduous wood.
MacDonald J, Doering M, Canam T, Gong Y, Guttman DS, Campbell MM, Master ER.
Appl Environ Microbiol. 2011 May;77(10):3211-8. doi: 10.1128/AEM.02490-10. Epub 2011 Mar 25.
PMID: 21441342
2010
Next-generation genomics of Pseudomonas syringae.
O'Brien HE, Desveaux D, Guttman DS.
Curr Opin Microbiol. 2011 Feb;14(1):24-30. doi: 10.1016/j.mib.2010.12.007. Epub 2011 Jan 12. Review.
PMID: 21233007

Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations.
Anderson JB, Funt J, Thompson DA, Prabhu S, Socha A, Sirjusingh C, Dettman JR, Parreiras L, Guttman DS, Regev A, Kohn LM.
Curr Biol. 2010 Aug 10;20(15):1383-8. doi: 10.1016/j.cub.2010.06.022. Epub 2010 Jul 15.
PMID: 20637622

Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein.
Lewis JD, Wu R, Guttman DS, Desveaux D.
PLoS Genet. 2010 Apr 1;6(4):e1000894. doi: 10.1371/journal.pgen.1000894.
PMID: 20368970

PAMDB, a multilocus sequence typing and analysis database and website for plant-associated microbes.
Almeida NF, Yan S, Cai R, Clarke CR, Morris CE, Schaad NW, Schuenzel EL, Lacy GH, Sun X, Jones JB, Castillo JA, Bull CT, Leman S, Guttman DS, Setubal JC, Vinatzer BA.
Phytopathology. 2010 Mar;100(3):208-15. doi: 10.1094/PHYTO-100-3-0208.
PMID: 20128693

Pseudomonas syringae strains naturally lacking the classical P. syringae hrp/hrc Locus are common leaf colonizers equipped with an atypical type III secretion system.
Clarke CR, Cai R, Studholme DJ, Guttman DS, Vinatzer BA.
Mol Plant Microbe Interact. 2010 Feb;23(2):198-210. doi: 10.1094/MPMI-23-2-0198.
PMID: 20064063
Older Publications
Bacterial evolution: dynamic genomes and the power of transformation.
Guttman DS.
Curr Biol. 2009 Sep 29;19(18):R857-9. doi: 10.1016/j.cub.2009.08.007.
PMID: 19788881

The targeting of plant cellular systems by injected type III effector proteins.
Lewis JD, Guttman DS, Desveaux D.
Semin Cell Dev Biol. 2009 Dec;20(9):1055-63. doi: 10.1016/j.semcdb.2009.06.003. Epub 2009 Jun 21. Review.
PMID: 19540926

Using a commercial DiversiLab semiautomated repetitive sequence-based PCR typing technique for identification of Escherichia coli clone ST131 producing CTX-M-15.
Pitout JD, Campbell L, Church DL, Wang PW, Guttman DS, Gregson DB.
J Clin Microbiol. 2009 Apr;47(4):1212-5. doi: 10.1128/JCM.02265-08. Epub 2009 Feb 9.
PMID: 19204095

Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems.
Zhou H, Morgan RL, Guttman DS, Ma W.
Mol Plant Microbe Interact. 2009 Feb;22(2):176-89. doi: 10.1094/MPMI-22-2-0176.
PMID: 19132870

A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass.
Singh S, Stavrinides J, Christendat D, Guttman DS.
Mol Biol Evol. 2008 Oct;25(10):2221-32. doi: 10.1093/molbev/msn170. Epub 2008 Jul 31.
PMID: 18669580

Evolution of prokaryotic and eukaryotic virulence effectors.
Ma W, Guttman DS.
Curr Opin Plant Biol. 2008 Aug;11(4):412-9. doi: 10.1016/j.pbi.2008.05.001. Epub 2008 Jun 26. Review.
PMID: 18585954

New and sensitive assay for determining Pseudomonas aeruginosa metallo-beta-lactamase resistance to imipenem.
Tan J, Pitout JD, Guttman DS.
J Clin Microbiol. 2008 May;46(5):1870-2. doi: 10.1128/JCM.02175-07. Epub 2008 Mar 12.
PMID: 18337388

The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thaliana.
Lewis JD, Abada W, Ma W, Guttman DS, Desveaux D.
J Bacteriol. 2008 Apr;190(8):2880-91. doi: 10.1128/JB.01702-07. Epub 2008 Feb 8.
PMID: 18263728

Evolution of the type III secretion system and its effectors in plant-microbe interactions.
McCann HC, Guttman DS.
New Phytol. 2008;177(1):33-47. Review.
PMID: 18078471

Host-pathogen interplay and the evolution of bacterial effectors.
Stavrinides J, McCann HC, Guttman DS.
Cell Microbiol. 2008 Feb;10(2):285-92. Epub 2007 Nov 21. Review.
PMID: 18034865

Convergent evolution of phytopathogenic pseudomonads onto hazelnut.
Wang PW, Morgan RL, Scortichini M, Guttman DS.
Microbiology. 2007 Jul;153(Pt 7):2067-73.
PMID: 17600051

Type III effector diversification via both pathoadaptation and horizontal transfer in response to a coevolutionary arms race.
Ma W, Dong FF, Stavrinides J, Guttman DS.
PLoS Genet. 2006 Dec;2(12):e209. Epub 2006 Oct 25.
PMID: 17194219

Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Vencato M, Tian F, Alfano JR, Buell CR, Cartinhour S, DeClerck GA, Guttman DS, Stavrinides J, Joardar V, Lindeberg M, Bronstein PA, Mansfield JW, Myers CR, Collmer A, Schneider DJ.
Mol Plant Microbe Interact. 2006 Nov;19(11):1193-206.
PMID: 17073302

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens.
Stavrinides J, Ma W, Guttman DS.
PLoS Pathog. 2006 Oct;2(10):e104.
PMID: 17040127

Comparative genomics of host-specific virulence in Pseudomonas syringae.
Sarkar SF, Gordon JS, Martin GB, Guttman DS.
Genetics. 2006 Oct;174(2):1041-56. Epub 2006 Sep 1.
PMID: 16951068

Diversifying selection drives the evolution of the type III secretion system pilus of Pseudomonas syringae.
Guttman DS, Gropp SJ, Morgan RL, Wang PW.
Mol Biol Evol. 2006 Dec;23(12):2342-54. Epub 2006 Sep 1.
PMID: 16950758

Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae.
Hwang MS, Morgan RL, Sarkar SF, Wang PW, Guttman DS.
Appl Environ Microbiol. 2005 Sep;71(9):5182-91.
PMID: 16151103

Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae.
Lindeberg M, Stavrinides J, Chang JH, Alfano JR, Collmer A, Dangl JL, Greenberg JT, Mansfield JW, Guttman DS.
Mol Plant Microbe Interact. 2005 Apr;18(4):275-82. Review.
PMID: 15828679

Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringae.
Rohmer L, Guttman DS, Dangl JL.
Genetics. 2004 Jul;167(3):1341-60.
PMID: 15280247

Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.
Stavrinides J, Guttman DS.
J Bacteriol. 2004 Aug;186(15):5101-15.
PMID: 15262947

Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.
Sarkar SF, Guttman DS.
Appl Environ Microbiol. 2004 Apr;70(4):1999-2012. Erratum in: Appl Environ Microbiol. 2008 Mar;74(6):1961.
PMID: 15066790

Plants as models for the study of human pathogenesis.
Guttman DS.
Biotechnol Adv. 2004 May;22(5):363-82. Review.
PMID: 15063457

The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.
Gropp SJ, Guttman DS.
Mol Plant Pathol. 2004 Mar 1;5(2):137-40. doi: 10.1111/j.1364-3703.2004.00212.x.
PMID: 20565590

Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.
Wang PW, Chu L, Guttman DS.
J Bacteriol. 2004 Jan;186(2):400-10.
PMID: 14702309

Mosaic evolution of the severe acute respiratory syndrome coronavirus.
Stavrinides J, Guttman DS.
J Virol. 2004 Jan;78(1):76-82.
PMID: 14671089

A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.
Guttman DS, Vinatzer BA, Sarkar SF, Ranall MV, Kettler G, Greenberg JT.
Science. 2002 Mar 1;295(5560):1722-6.
PMID: 11872842

Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system.
Guttman DS, Greenberg JT.
Mol Plant Microbe Interact. 2001 Feb;14(2):145-55.
PMID: 11204777

The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth.
Rate DN, Cuenca JV, Bowman GR, Guttman DS, Greenberg JT.
Plant Cell. 1999 Sep;11(9):1695-708.
PMID: 10488236

An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.
Guttman DS, Charlesworth D.
Nature. 1998 May 21;393(6682):263-6.
PMID: 9607762

Lack of degeneration of loci on the neo-Y chromosome of Drosophila americana americana.
Charlesworth B, Charlesworth D, Hnilicka J, Yu A, Guttman DS.
Genetics. 1997 Apr;145(4):989-1002.
PMID: 9093852

Recombination and clonality in natural populations of Escherichia coli.
Guttman DS.
Trends Ecol Evol. 1997 Jan;12(1):16-22.
PMID: 21237956

Seeing selection in S allele sequences.
Charlesworth D, Guttman DS.
Curr Biol. 1997 Jan 1;7(1):R34-7.
PMID: 9072167

Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Guttman DS, Wang PW, Wang IN, Bosler EM, Luft BJ, Dykhuizen DE.
J Clin Microbiol. 1996 Mar;34(3):652-6.
PMID: 8904432

Detecting selective sweeps in naturally occurring Escherichia coli.
Guttman DS, Dykhuizen DE.
Genetics. 1994 Dec;138(4):993-1003.
PMID: 7896119

Clonal divergence in Escherichia coli as a result of recombination, not mutation.
Guttman DS, Dykhuizen DE.
Science. 1994 Nov 25;266(5189):1380-3.
PMID: 7973728

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